2'-Fosfotransferaza
(преусмерено са 2'-fosfotransferaza)
| 2'-fosfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.160 | ||||||||
| CAS broj | 126905-00-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2'-fosfotransferaza (EC 2.7.1.160, kvaščana 2'-fosfotransferaza, Tpt1, Tpt1p, 2'-fosfo-tRNK:NAD+ fosfotransferaza) je enzim sa sistematskim imenom 2'-fosfo-(ligirana tRNK):NAD+ fosfotransferaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2'-fosfo-[tRNK] + NAD+ tRNK + ADP-riboza 1,2-fosfat + nikotinamid +H2O
Ovaj enzim katalizuje finalni korak tRNK splajsovanja u kvascu Saccharomyces cerevisiae.
Reference[уреди | уреди извор]
- ^ Steiger, M.A., Kierzek, R., Turner, D.H. and Phizicky, E.M. (2001). „Substrate recognition by a yeast 2′-phosphotransferase involved in tRNA splicing and by its Escherichia coli homolog”. Biochemistry. 40: 14098—14105. PMID 11705403.
- ^ Spinelli, S.L., Kierzek, R., Turner, D.H. and Phizicky, E.M. (1999). „Transient ADP-ribosylation of a 2′-phosphate implicated in its removal from ligated tRNA during splicing in yeast”. J. Biol. Chem. 274: 2637—2644. PMID 9915792.
- ^ Culver, G.M., McCraith, S.M., Consaul, S.A., Stanford, D.R. and Phizicky, E.M. (1997). „A 2′-phosphotransferase implicated in tRNA splicing is essential in Saccharomyces cerevisiae”. J. Biol. Chem. 272: 13203—13210. PMID 9148937.
- ^ McCraith, S.M. & Phizicky, E.M. (1991). „An enzyme from Saccharomyces cerevisiae uses NAD+ to transfer the splice junction 2′-phosphate from ligated tRNA to an acceptor molecule”. J. Biol. Chem. 266: 11986—11992. PMID 2050693.
- ^ Hu, Q.D., Lu, H., Huo, K., Ying, K., Li, J., Xie, Y., Mao, Y. and Li, Y.Y. (2003). „A human homolog of the yeast gene encoding tRNA 2′-phosphotransferase: cloning, characterization and complementation analysis”. Cell. Mol. Life Sci. 60: 1725—1732. PMID 14504659.
- ^ Steiger, M.A., Jackman, J.E. and Phizicky, E.M. (2005). „Analysis of 2′-phosphotransferase (Tpt1p) from Saccharomyces cerevisiae: evidence for a conserved two-step reaction mechanism”. RNA. 11: 99—106. PMID 15611300.
- ^ Sawaya, R., Schwer, B. and Shuman, S. (2005). „Structure-function analysis of the yeast NAD+-dependent tRNA 2′-phosphotransferase Tpt1”. RNA. 11: 107—113. PMID 15611301.
- ^ Kato-Murayama, M., Bessho, Y., Shirouzu, M. and Yokoyama, S. (2005). „Crystal structure of the RNA 2′-phosphotransferase from Aeropyrum pernix K1”. J. Mol. Biol. 348: 295—305. PMID 15811369.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- 2'-phosphotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
