2-Hidroksimukonatna tautomeraza
| 2-Hidroksimukonatna tautomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.3.2.6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-Hidroksimukonatna tautomeraza (EC 5.3.2.6, 4-oksalokrotonatna tautomeraza, 4-oksalokrotonatna izomeraza, cnbG (gen), praC (gen), xylH (gen)) je enzim sa sistematskim imenom (2Z,4E)-2-hidroksiheksa-2,4-dienedioat keto—enol izomeraza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2Z,4E)-2-hidroksiheksa-2,4-dienedioat (3E)-2-oksoheks-3-enedioat
Ovaj enzim učestvuje u putu meta-odvajanja tokom degradacije fenola.
Reference[уреди | уреди извор]
- ^ Whitman, C.P., Aird, B.A., Gillespie, W.R. and Stolowich, N.J. (1991). „Chemical and enzymatic ketonization of 2-hydroxymuconate, a conjugated enol”. J. Am. Chem. Soc. 113: 3154—3162.
- ^ Whitman, C.P., Hajipour, G., Watson, R.J., Johnson, W.H., Jr., Bembenek, M.E. and Stolowich, N.J. (1992). „Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase”. J. Am. Chem. Soc. 114: 10104—10110.
- ^ Subramanya, H.S., Roper, D.I., Dauter, Z., Dodson, E.J., Davies, G.J., Wilson, K.S. and Wigley, D.B. (1996). „Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases”. Biochemistry. 35: 792—802. PMID 8547259.
- ^ Stivers, J.T., Abeygunawardana, C., Mildvan, A.S., Hajipour, G., Whitman, C.P. and Chen, L.H. (1996). „Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies”. Biochemistry. 35: 803—813. PMID 8547260.
- ^ Wang, S.C., Johnson, W.H., Jr., Czerwinski, R.M., Stamps, S.L. and Whitman, C.P. (2007). „Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions”. Biochemistry. 46: 11919—11929. PMID 17902707.
- ^ Kasai, D., Fujinami, T., Abe, T., Mase, K., Katayama, Y., Fukuda, M. and Masai, E. (2009). „Uncovering the protocatechuate 2,3-cleavage pathway genes”. J. Bacteriol. 191: 6758—6768. PMID 19717587.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 2-hydroxymuconate+tautomerase на US National Library of Medicine Medical Subject Headings (MeSH)
