23S rRNK pseudouridinska1911/1915/1917 sintaza
| 23S rRNK pseudouridinska1911/1915/1917 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.23 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK pseudouridinska1911/1915/1917 sintaza (EC 5.4.99.23, RluD, pseudouridinska sintaza RluD) je enzim sa sistematskim imenom 23S rRNK-uridin1911/1915/1917 uracil mutaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 23S rRNK uridin1911/uridin1915/uridin1917 23S rRNK pseudouridin1911/pseudouridin1915/pseudouridin1917
Pseudouridinska sintaza RluD konvertuje uridine u pozicijama 1911, 1915, i 1917 molekula 23S rRNK do pseudouridina.
Reference
[уреди | уреди извор]- ^ Leppik, M., Peil, L., Kipper, K., Liiv, A. and Remme, J. (2007). „Substrate specificity of the pseudouridine synthase RluD in Escherichia coli”. FEBS J. 274: 5759—5766. PMID 17937767.
- ^ Ejby, M., Sorensen, M.A. and Pedersen, S. (2007). „Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination”. Proc. Natl. Acad. Sci. USA. 104: 19410—19415. PMID 18032607.
- ^ Sivaraman, J., Iannuzzi, P., Cygler, M. and Matte, A. (2004). „Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli”. J. Mol. Biol. 335: 87—101. PMID 14659742.
- ^ Wrzesinski, J., Bakin, A., Ofengand, J. and Lane, B.G. (2000). „Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)”. IUBMB Life. 50: 33—37. PMID 11087118.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- 23S+rRNA+pseudouridine1911/1915/1917+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
