8-Okso-dGDP fosfataza
| 8-Okso-dGDP fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.58 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
8-Okso-dGDP fosfataza (EC 3.6.1.58, NUDT5) je enzim sa sistematskim imenom 8-okso-dGDP fosfohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 8-okso-dGDP + H2O 8-okso-dGMP + fosfat
Ovaj enzim katalizuje hidrolizu 8-okso-dGDP i 8-okso-GDP.
Reference[уреди | уреди извор]
- ^ Ishibashi, T., Hayakawa, H., Ito, R., Miyazawa, M., Yamagata, Y. and Sekiguchi, M. (2005). „Mammalian enzymes for preventing transcriptional errors caused by oxidative damage”. Nucleic Acids Res. 33: 3779—3784. PMID 16002790.
- ^ Ishibashi, T., Hayakawa, H. and Sekiguchi, M. (2003). „A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides”. EMBO Rep. 4: 479—483. PMID 12717453.
- ^ Kamiya, H., Hori, M., Arimori, T., Sekiguchi, M., Yamagata, Y. and Harashima, H. (2009). „NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity”. DNA Repair (Amst). 8: 1250—1254. PMID 19699693.
- ^ Ito, R., Sekiguchi, M., Setoyama, D., Nakatsu, Y., Yamagata, Y. and Hayakawa, H. (2011). „Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein”. J. Biochem. 149: 731—738. PMID 21389046.
- ^ Zha, M., Zhong, C., Peng, Y., Hu, H. and Ding, J. (2006). „Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity”. J. Mol. Biol. 364: 1021—1033. PMID 17052728.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 8-oxo-dGDP+phosphatase на US National Library of Medicine Medical Subject Headings (MeSH)
