Acil-KoA dehidrogenaza dugog lanca
| Acil-KoA dehidrogenaza dugog lanca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.8.8 | ||||||||
| CAS broj | 59536-74-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Acil-KoA dehidrogenaza dugog lanca (EC 1.3.8.8, palmitoil-KoA dehidrogenaza, palmitoil-koenzim A dehidrogenaza, acil-koenzim A dehidrogenaza dugog lanca, acil-KoA dugog lanca:(akceptor) 2,3-oksidoreduktaza, ACADL (gen).) je enzim sa sistematskim imenom acil-KoA dugog lanca:elektron-transfer flavoprotein 2,3-oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dugolančani acil-KoA + elektron-transfer flavoprotein dugolančani trans-2,3-dehidroacil-KoA + redukovani elektron-transfer flavoprotein
Ovaj enzim dadrži FAD kao prostetičku grupu. On je jedan od nekoliko enzima koji katalizuju prvi kora u beta oksidaciji masnih kiselina.
Reference[уреди | уреди извор]
- ^ Crane, F.L., Hauge, J.G. and Beinert, H. (1955). „Flavoproteins involved in the first oxidative step of the fatty acid cycle”. Biochim. Biophys. Acta. 17: 292—294. PMID 13239683.
- ^ Hauge, J.G., Crane, F.L. and Beinert, H. (1956). „On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl CoA dehydrogenase”. J. Biol. Chem. 219: 727—733. PMID 13319294.
- ^ Hall, C.L., Heijkenkjold, L., Bartfai, T., Ernster, L. and Kamin, H. (1976). „Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef heart mitochondria”. Arch. Biochem. Biophys. 177: 402—414. PMID 1015826.
- ^ Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). „Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme”. J. Biol. Chem. 260: 1311—1325. PMID 3968063.
- ^ Djordjevic, S., Dong, Y., Paschke, R., Frerman, F.E., Strauss, A.W. and Kim, J.J. (1994). „Identification of the catalytic base in long chain acyl-CoA dehydrogenase”. Biochemistry. 33: 4258—4264. PMID 8155643.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Long-chain+acyl-CoA+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
