C5a peptidaza
| C5a peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.110 | ||||||||
| CAS broj | 100179-39-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
C5a peptidaza (EC 3.4.21.110, streptokokalna C5a peptidaza, ScpA, ScpB, SCPA) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Primarno dolazi do razlaganja u pozciji His67-Lys68 u ljudskom C5a, i u manjoj meri u poziciji Ala58-Ser59
Ovaj enzim za površinu vezana subtilisinu slična serinska peptidaza sa veoma uskom supstratnom specifičnošću.
Reference[уреди | уреди извор]
- ^ Wexler, D.E., Chenoweth, D.E. and Cleary, P.P. (1985). „Mechanism of action of the group A streptococcal C5a inactivator”. Proc. Natl. Acad. Sci. USA. 82: 8144—8148. PMID 3906656.
- ^ Bohnsack, J.F., Mollison, K.W., Buko, A.M., Ashworth, J.C. and Hill, H.R. (1991). „Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus”. Biochem. J. 273: 635—640. PMID 1996961.
- ^ Cleary, P.P., Prahbu, U., Dale, J.B., Wexler, D.E. and Handley, J. (1992). „Streptococcal C5a peptidase is a highly specific endopeptidase”. Infect. Immun. 60: 5219—5223. PMID 1452354.
- ^ Anderson, E.T., Wetherell, M.G., Winter, L.A., Olmsted, S.B., Cleary, P.P. and Matsuka, Y.V. (2002). „Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes”. Eur. J. Biochem. 269: 4839—4851. PMID 12354115.
- ^ Stafslien, D.K. & Cleary, P.P. (2000). „Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate”. J. Bacteriol. 182: 3254—3258. PMID 10809707.
- ^ Terao, Y., Yamaguchi, M., Hamada, S. and Kawabata, S. (2006). „Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils”. J. Biol. Chem. 281: 14215—14223. PMID 16565520.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- C5a+peptidase на US National Library of Medicine Medical Subject Headings (MeSH)
