Deacetoksivindolin 4-hidroksilaza
| Deacetoksivindolin 4-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.20 | ||||||||
| CAS broj | 132084-83-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Deacetoksivindolin 4-hidroksilaza (EC 1.14.11.20, desacetoksivindolinska 4-hidroksilaza, desacetioksivindolin-17-hidroksilaza, D17H, desacetoksivindolin,2-oksoglutarat:kiseonik oksidoreduktaza (4beta-hidroksilacija)) je enzim sa sistematskim imenom deacetoksivindolin,2-oksoglutarat:kiseonik oksidoreduktaza (4beta-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- deacetoksivindolin + 2-oksoglutarat + O2 deacetilvindolin + sukcinat + CO2
Za rad ovog enzima se neophodni Fe2+ i askorbat. On takođe deluje na 3-hidroksi-16-metoksi-2,3-dihidrotabersonin i u manjoj meri na 16-metoksi-2,3-dihidrotabersonin.
Reference[уреди | уреди извор]
- ^ De Carolis, E., Chan, F., Balsevich, J. and De Luca, V. (1990). „Isolation and characterization of a 2-oxoglutarate dependent dioxygenase involved in the 2nd-to-last step in vindoline biosynthesis”. Plant Physiol. 94: 1323—1329. PMID 16667836.
- ^ De Carolis, E. & De Luca, V. (1993). „Purification, characterization, and kinetic analysis of a 2-oxoglutarate-dependent dioxygenase involved in vindoline biosynthesis from Catharanthus roseus”. J. Biol. Chem. 268: 5504—5511. PMID 8449913.
- ^ Vazquez-Flota, F.A. & De Luca, V. (1998). „Developmental and light regulation of desacetoxyvindoline 4-hydroxylase in Catharanthus roseus (L.) G. Don. Evidence of a multilevel regulatory mechanism”. Plant Physiol. 117: 1351—1361. PMID 9701591.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Deacetoxyvindoline+4-hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)
