Diacetil reduktaza (formira (S)-acetoin)
| Diacetil reduktaza (formira (S)-acetoin) | |||||||||
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| Identifikatori | |||||||||
| EC broj | 1.1.1.304 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Diacetil reduktaza (formira (S)-acetoin) (EC 1.1.1.304, (S)-acetoinska dehidrogenaza) je enzim sa sistematskim imenom (S)-acetoin:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-acetoin + NAD+ diacetil + NADH + H+
Ova reakcija je katalizovana u reverznom smeru. Ta aktivnost je obično vezana za dejstvo butandiolne dehidrogenaze (EC 1.1.1.4 ili EC 1.1.1.76). Dok je dejstvo butandiolne dehidrogenaze reverzibilno, dejstvo diacetil reduktaze je ireverzibilno. Ovaj enzim je izražen u Geobacillus steardrugemophilus, Enterobacter aerogenes i Klebsiella pneumoniae.
Reference[уреди | уреди извор]
- ^ Giovannini, P.P., Medici, A., Bergamini, C.M. and Rippa, M. (1996). „Properties of diacetyl (acetoin) reductase from Bacillus stearothermophilus”. Bioorg. Med. Chem. 4: 1197—1201. PMID 8879540.
- ^ Carballo, J., Martin, R., Bernardo, A. and Gonzalez, J. (1991). „Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes”. Eur. J. Biochem. 198: 327—332. PMID 2040298.
- ^ Ui, S., Okajima, Y., Mimura, A., Kanai, H., Kobayashi, T., Kudo, T. (1997). „Sequence analysis of the gene for and characterization of D-acetoin forming meso-2,3-butanediol dehydrogenase of Klebsiella pneumoniae expressed in Escherichia coli”. J. Ferment. Bioeng. 83: 32—37.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Diacetyl+reductase+((S)-acetoin+forming) на US National Library of Medicine Medical Subject Headings (MeSH)
