Protein-L-izoaspartat(D-aspartat) O-metiltransferaza
| Protein-L-izoaspartat(D-aspartat) O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.77 | ||||||||
| CAS broj | 105638-50-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Protein-L-izoaspartat(D-aspartat) O-metiltransferaza (EC 2.1.1.77, protein-L-izoaspartatna O-metiltransferaza, protein-beta-aspartatna O-metiltransferaza, D-aspartil/L-izoaspartilna metiltransferaza, L-izoaspartil/D-aspartil protein karboksilna metiltransferaza, proteinska (D-aspartat) metiltransferaza, protein D-aspartatna metiltransferaza, protein L-izoaspartatna metiltransferaza, protein L-izoaspartilna metiltransferaza, proteinska O-metiltransferaza (L-izoaspartat), L-aspartil/L-izoaspartil proteinska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:protein-L-izoaspartat O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + protein L-izoaspartat S-adenozil-L-homocistein + protein L-izoaspartat alfa-metil estar
D-aspartat ostatak unutar proteina takođe može da bude akceptor.
Reference
[уреди | уреди извор]- ^ Aswad, D.W. & Johnson, B.A. (1987). „The unusual substrate-specificity of eukaryotic protein carboxyl methyltransferases”. Trends Biochem. Sci. 12: 155—158.
- ^ Clarke, S. (1985). „Protein carboxyl methyltransferases: two distinct classes of enzymes”. Annu. Rev. Biochem. 54: 479—506. PMID 3896126.
- ^ Kim, S. & Paik, W.K. (1970). „Purification and properties of protein methylase II”. J. Biol. Chem. 245: 1806—1813. PMID 5438363.
- ^ Ota, I.M., Ding, L. and Clarke, S. (1987). „Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase”. J. Biol. Chem. 262: 8522—8531. PMID 3597386.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Protein-L-isoaspartate(D-aspartate)+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
