Fosfonoacetaldehidna hidrolaza
(преусмерено са Fosfonoacetaldehid hidrolaza)
| Fosfonoacetaldehidna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.11.1.1 | ||||||||
| CAS broj | 37289-42-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfonoacetaldehidna hidrolaza (EC 3.11.1.1, fosfonataza, 2-fosfonoacetilaldehidna fosfonohidrolaza) je enzim sa sistematskim imenom 2-oksoetilfosfonat fosfonohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfonoacetaldehid + H2O acetaldehid + fosfat
Ovaj enzim destabilizuje C-P vezu, putem formiranja imina između lizinskih ostataka i karbonilnih grupa supstrata.
Reference[уреди | уреди извор]
- ^ La Nauze, J.M. & Rosenberg, H. (1968). „The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus”. Biochim. Biophys. Acta. 165: 438—447. PMID 4982500.
- ^ La Nauze, J.M., Rosenberg, H. and Shaw, D.C. (1970). „The enzymic cleavage of the carbon-phosphorus bond: purification and properties of phosphonatase”. Biochim. Biophys. Acta. 212: 332—350. PMID 4989158.
- ^ La Nauze, J.M., Coggins, J.R. and Dixon, H.B.F. (1977). „Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase”. Biochem. J. 165: 409—411. PMID 200222.
- ^ Olsen, D.B., Hepburn, T.W., Moos, M., Mariano, P.S. and Dunaway-Mariano, D. (1988). „Substrate binding and catalytic groups of the P-C bond cleaving enzyme, phosphonoacetaldehyde hydrolase”. Biochemistry. 27: 2229—2234. PMID 3132206.
- ^ Baker, A.S., Ciocci, M.J., Metcalf, W.W., Kim, J., Babbitt, P.C., Wanner, B.L., Martin, B.M. and Dunaway-Mariano, D. (1998). „Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis”. Biochemistry. 37: 9305—9315. PMID 9649311.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Phosphonoacetaldehyde+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
