Galaktonolakton dehidrogenaza
| Galaktonolakton dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.2.3 | ||||||||
| CAS broj | 2603847 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Galaktonolakton dehidrogenaza (EC 1.3.2.3, L-galaktono-gama-laktonska dehidrogenaza, L-galaktono-gama-lakton:fericitohrom-c oksidoreduktaza, GLDHaza, GLDazae) je enzim sa sistematskim imenom L-galaktono-1,4-lakton:fericitohrom-c oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) L-galakto-1,4-lakton + 2 fericitohrom c L-askorbat + 2 ferocitohrom c + 2 H+;;
- (2) L-askorbat + 2 fericitohrom c L-dehidroaskorbat + 2 ferocitohrom c + 2 H+ (spontaneous)
Ovaj enzim katalizuje finalni korak biosinteze L-askorbnske kiseline kod viših biljki i kod skoro svih viših životinja izuzev primata i nekih ptica. Enzim je veoma specifičana za svoj supstrat L-galaktono-1,4-lakton, dok D-galaktono-gama-lakton, D-gulono-gama-lakton, L-gulono-gama-lakton, D-eritronski-gama-lakton, D-ksilonski-gama-lakton, L-manono-gama-lakton, D-galaktonat, D-glukuronat i D-glukonat nisu supstrati.
Reference[уреди | уреди извор]
- ^ Mapson, L.W. & Breslow, E. (1957). „Properties of partially purified L-galactono-γ-lactone dehydrogenase”. Biochem. J. 65: 29—29.
- ^ Mapson, L.W., Isherwood, F.A. and Chen, Y.T. (1954). „Biological synthesis of L-ascorbic acid: the conversion of L-galactono-γ-lactone into L-ascorbic acid by plant mitochondria”. Biochem. J. 56: 21—28. PMID 13126087.
- ^ Isherwood, F.A., Chen, Y.T. and Mapson, L.W. (1954). „Synthesis of L-ascorbic acid in plants and animals.”. Biochem. J. 56: 1—15. PMID 13126085.
- ^ Ôba, K., Ishikawa, S., Nishikawa, M., Mizuno, H. and Yamamoto, T. (1995). „Purification and properties of L-galactono-γ-lactone dehydrogenase, a key enzyme for ascorbic acid biosynthesis, from sweet potato roots”. J. Biochem. (Tokyo). 117: 120—124. PMID 7775377.
- ^ Østergaard, J., Persiau, G., Davey, M.W., Bauw, G. and Van Montagu, M. (1997). „Isolation of a cDNA coding for L-galactono-γ-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast”. J. Biol. Chem. 272: 30009—30016. PMID 9374475.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- L-galactonolactone+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
