Germakren A alkohol dehidrogenaza
| Germakren A alkohol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.314 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Germakren A alkohol dehidrogenaza (EC 1.1.1.314, germakren A alkoholna dehidrogenaza) je enzim sa sistematskim imenom germakra-1(10),4,11(13)-trien-12-ol:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- germakra-1(10),4,11(13)-trien-12-ol + 2 NADP+ +H2O germakra-1(10),4,11(13)-trien-12-oat + 2 NADPH + 3 H+ (sveukupna reakcija)
- (1a) germakra-1(10),4,11(13)-trien-12-ol + NADP+ germakra-1(10),4,11(13)-trien-12-al + NADPH + H+
- (1b) germakra-1(10),4,11(13)-trien-12-al + NADP+ +H2O germakra-1(10),4,11(13)-trin-12-oat + NADPH + 2 H+
Kod Lactuca sativa ovaj enzim je mutifunkcionalan. On takođe deluje kao EC 1.14.13.123, germakren A hidroksilaza.
Reference[уреди | уреди извор]
- ^ de Kraker, J.W., Franssen, M.C., Dalm, M.C., de Groot, A. and Bouwmeester, H.J. (2001). „Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene A hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis”. Plant Physiol. 125: 1930—1940. PMID 11299372.
- ^ Nguyen, D.T., Gopfert, J.C., Ikezawa, N., Macnevin, G., Kathiresan, M., Conrad, J., Spring, O. and Ro, D.K. (2010). „Biochemical conservation and evolution of germacrene A oxidase in asteraceae”. J. Biol. Chem. 285: 16588—16598. PMID 20351109.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Germacrene+A+alcohol+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
