Glicilpeptid N-tetradekanoiltransferaza
| Glicilpeptid N-tetradekanoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.97 | ||||||||
| CAS broj | 110071-61-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glicilpeptid N-tetradekanoiltransferaza (EC 2.3.1.97, peptid N-miristoiltransferaza, miristoil-KoA-protein N-miristoiltransferaza, miristoil-koenzim A:protein N-miristoil transferaza, miristoilacioni enzim, protein N-miristoiltransferaza) je enzim sa sistematskim imenom tetradekanoil-KoA:glicilpeptid N-tetradekanoiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tetradekanoil-KoA + glicilpeptid KoA + N-tetradekanoilglicilpeptid
Enzim iz kvasca je veoma specifičan za tetradekanoil-KoA, za N-terminalni glicin u oligopeptidima koji sadrže serin u 5-pozicija. Enzim iz srca sisara prenosi grupe na specifične 51 kDa akceptorske proteine.
Reference[уреди | уреди извор]
- ^ Guertin, D., Gris-Miron, L. and Riendeau, D. (1986). „Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue”. Biochem. Cell Biol. 64: 1249—1255. PMID 3566958.
- ^ Heuckeroth, R.O., Towler, D.A., Adams, S.P., Glaser, L. and Gordon, J.I. (1988). „11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase”. J. Biol. Chem. 263: 2127—2133. PMID 3123489.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Glycylpeptide+N-tetradecanoyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
