HTR3A

Из Википедије, слободне енциклопедије
5-hidroksitriptaminski (serotoninski) receptor 3A, jonotropni
Identifikatori
Simboli HTR3A; 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3
Vanjski ID OMIM182139 MGI96282 HomoloGene671 IUPHAR: 5-HT3A GeneCards: HTR3A Gene
Pregled RNK izražavanja
PBB GE HTR3A 216615 s at tn.png
PBB GE HTR3A 217002 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3359 15561
Ensembl ENSG00000166736 ENSMUSG00000032269
UniProt P46098 P23979
RefSeq (mRNA) NM_000869 NM_001099644
RefSeq (protein) NP_000860 NP_001093114
Lokacija (UCSC) Chr 11:
113.85 - 113.86 Mb
Chr 9:
48.9 - 48.91 Mb
PubMed pretraga [1] [2]

5-hidroksitriptaminski receptor 3A je protein koji je kod čoveka kodiran HTR3A genom.[1][2]

Produkt ovog gena pripada receptorskoj familiji ligandom konstrolisanih jonskih kanala. Ovaj gen kodira podjedinicu A tipa 3 receptora za 5-hidroksitriptamin (serotonin), biogeni hormon koji deluje kao neurotransmiter, hormon, i mitogen. Ovaj receptor uzrokujue brze, depolaricione response u neuronima nakon aktivacije. Heteromerna kombinacija A i B podjedinica je neophodna da bi se formirao potpuno funkcionalni receptor. Homomerni receptor bilo koja podjednice imaju veoma nisku provodnost i malu amplitudu responsa. Alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su poznate.[3]

Vidi još[уреди]

Reference[уреди]

  1. Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (1996). „Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2”. Genomics 29 (1): 304—5. doi:10.1006/geno.1995.1254. PMID 8530095. 
  2. Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (2003). „A cytoplasmic region determines single-channel conductance in 5-HT3 receptors”. Nature 424 (6946): 321—4. doi:10.1038/nature01788. PMID 12867984. 
  3. „Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A”. 

Literatura[уреди]

  • Miyake A, Mochizuki S, Takemoto Y, Akuzawa S (1995). „Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.”. Mol. Pharmacol. 48 (3): 407—16. PMID 7565620. 
  • Uetz P, Abdelatty F, Villarroel A; et al. (1994). „Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.”. FEBS Lett. 339 (3): 302—6. doi:10.1016/0014-5793(94)80435-4. PMID 8112471. 
  • Belelli D, Balcarek JM, Hope AG; et al. (1996). „Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.”. Mol. Pharmacol. 48 (6): 1054—62. PMID 8848005. 
  • Brüss M, Göthert M, Hayer M, Bönisch H (1999). „Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs.”. Ann. N. Y. Acad. Sci. 861: 234—5. doi:10.1111/j.1749-6632.1998.tb10196.x. PMID 9928262. 
  • Davies PA, Pistis M, Hanna MC; et al. (1999). „The 5-HT3B subunit is a major determinant of serotonin-receptor function.”. Nature 397 (6717): 359—63. doi:10.1038/16941. PMID 9950429. 
  • Brüss M, Eucker T, Göthert M, Bönisch H (2000). „Exon-intron organization of the human 5-HT3A receptor gene.”. Neuropharmacology 39 (2): 308—15. doi:10.1016/S0028-3908(99)00116-1. PMID 10670426. 
  • Marazziti D, Betti L, Giannaccini G; et al. (2002). „Distribution of [3H]GR65630 binding in human brain postmortem.”. Neurochem. Res. 26 (3): 187—90. doi:10.1023/A:1010939530412. PMID 11495540. 
  • Spier AD, Lummis SC (2003). „Immunological characterization of 5-HT3 receptor transmembrane topology.”. J. Mol. Neurosci. 18 (3): 169—78. doi:10.1385/JMN:18:3:169. PMID 12059035. 
  • Boyd GW, Low P, Dunlop JI; et al. (2002). „Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins.”. Mol. Cell. Neurosci. 21 (1): 38—50. doi:10.1006/mcne.2002.1160. PMID 12359150. 
  • Hapfelmeier G, Haseneder R, Lampadius K; et al. (2003). „Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics.”. Neurosci. Lett. 335 (1): 44—8. doi:10.1016/S0304-3940(02)01156-4. PMID 12457738. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Pick H, Preuss AK, Mayer M; et al. (2003). „Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells”. Biochemistry 42 (4): 877—84. doi:10.1021/bi026576d. PMID 12549905. 
  • Choi S, Lee JH, Oh S; et al. (2003). „Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes”. Mol. Cells 15 (1): 108—13. PMID 12661769. 
  • Boyd GW, Doward AI, Kirkness EF; et al. (2003). „Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal”. J. Biol. Chem. 278 (30): 27681—7. doi:10.1074/jbc.M304938200. PMID 12750374. 
  • Sun H, Hu XQ, Moradel EM; et al. (2003). „Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C”. J. Biol. Chem. 278 (36): 34150—7. doi:10.1074/jbc.M303584200. PMID 12791692. 
  • Maksay G, Bikádi Z, Simonyi M (2004). „Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models”. J. Recept. Signal Transduct. Res. 23 (2–3): 255—70. doi:10.1081/RRS-120025568. PMID 14626451. 
  • Kaiser R, Tremblay PB, Sezer O; et al. (2004). „Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists”. Pharmacogenetics 14 (5): 271—8. doi:10.1097/00008571-200405000-00001. PMID 15115912. 
  • Panicker S, Cruz H, Arrabit C; et al. (2004). „Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor”. J. Biol. Chem. 279 (27): 28149—58. doi:10.1074/jbc.M403545200. PMID 15131114. 

Spoljašnje veze[уреди]