Heparanaza
| Heparanaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.166 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Heparanaza (EC 3.2.1.166, Hpa1 heparanaza, Hpa1, heparanaza 1, heparanaza-1, C1A heparanaza, HPSE) je enzim sa sistematskim imenom heparan sulfat N-sulfo-D-glukozamin endoglukanaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- endohidroliza (1->4)-beta-D-glikozidnih veza heparan sulfatnih lanaca u heparan sulfatnom proteoglikanu
Heparanaza razlaže veze između glukuronsko kiselinskih jedinica i N-sulfo glukozaminskih jedinica koje nose bilo 3-O-sulfo ili 6-O-sulfo grupe.
Reference
[уреди | уреди извор]- ^ Bame, K.J. (2001). „Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans”. Glycobiology. 11: 91R—98R. PMID 11445547.
- ^ Peterson, S.B. & Liu, J. (2010). „Unraveling the specificity of heparanase utilizing synthetic substrates”. J. Biol. Chem. 285: 14504—14513. PMID 20181948.
- ^ Pikas, D.S., Li, J.P., Vlodavsky, I. and Lindahl, U. (1998). „Substrate specificity of heparanases from human hepatoma and platelets”. J. Biol. Chem. 273: 18770—18777. PMID 9668050.
- ^ Okada, Y., Yamada, S., Toyoshima, M., Dong, J., Nakajima, M. and Sugahara, K. (2002). „Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence”. J. Biol. Chem. 277: 42488—42495. PMID 12213822.
- ^ Vreys, V. & David, G. (2007). „Mammalian heparanase: what is the message”. J. Cell. Mol. Med. 11: 427—452. PMID 17635638.
- ^ Gong, F., Jemth, P., Escobar Galvis, M.L., Vlodavsky, I., Horner, A., Lindahl, U. and Li, J.P. (2003). „Processing of macromolecular heparin by heparanase”. J. Biol. Chem. 278: 35152—35158. PMID 12837765.
- ^ Toyoshima, M. & Nakajima, M. (1999). „Human heparanase. Purification, characterization, cloning, and expression”. J. Biol. Chem. 274: 24153—24160. PMID 10446189.
- ^ Miao, H.Q., Navarro, E., Patel, S., Sargent, D., Koo, H., Wan, H., Plata, A., Zhou, Q., Ludwig, D., Bohlen, P. and Kussie, P. (2002). „Cloning, expression, and purification of mouse heparanase”. Protein Expr. Purif. 26: 425—431. PMID 12460766.
- ^ Hammond, E., Li, C.P. and Ferro, V. (2010). „Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening”. Anal. Biochem. 396: 112—116. PMID 19748475.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Heparanase на US National Library of Medicine Medical Subject Headings (MeSH)
