Hidrolaza nezasićenog hondroitinskog disaharida
| Hidrolaza nezasićenog hondroitinskog disaharida | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.180 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hidrolaza nezasićenog hondroitinskog disaharida (EC 3.2.1.180, UGL, hidrolaza nezasićenog glukuronila) je enzim sa sistematskim imenom beta-D-4-dezoksi-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- beta-D-4-dezoksi-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O 5-dehidro-4-dezoksi-D-glukuronat + N-acetil-beta-D-galaktozamin-6-O-sulfat
Ovaj enzim odvaja 4-dezoksi-4,5-didehidro D-glukuronsku kiselinu ili 4-dezoksi-4,5-didehidro L-iduronsku kiselinu sa hondroitin disaharida, hijaluronan disaharida i heparin disaharida.
Reference[уреди | уреди извор]
- ^ Maruyama, Y., Nakamichi, Y., Itoh, T., Mikami, B., Hashimoto, W. and Murata, K. (2009). „Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan”. J. Biol. Chem. 284: 18059—18069. PMID 19416976.
- ^ Nakamichi, Y., Maruyama, Y., Mikami, B., Hashimoto, W. and Murata, K. (2011). „Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups”. J. Biol. Chem. 286: 6262—6271. PMID 21147778.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Unsaturated+chondroitin+disaccharide+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
