Hinat/šikimat dehidrogenaza
| Hinat/šikimat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.282 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hinat/šikimat dehidrogenaza (EC 1.1.1.282, YdiB) je enzim sa sistematskim imenom L-hinat:NAD(P)+ 3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) L-hinat + NAD(P)+ 3-dehidrohinat + NAD(P)H + H+
- (2) šikimat + NAD(P)+ 3-dehidrošikimat + NAD(P)H + H+
Ovo je drugi enzim šikimatne dehidrogenaze nađen kod Escherichia coli. On se razlikuje od EC 1.1.1.25, šikimatne dehidrogenaze, po tome što može da koristi hinat I šikimat kao supstrat, i bilo NAD+ ili NADP+ kao akceptor.
Reference[уреди | уреди извор]
- ^ Michel, G., Roszak, A.W., Sauvé, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. (2003). „Structures of shikimate dehydrogenase AroE and its paralog YdiB. A common structural framework for different activities”. J. Biol. Chem. 278: 19463—19472. PMID 12637497.
- ^ Benach, J., Lee, I., Edstrom, W., Kuzin, A.P., Chiang, Y., Acton, T.B., Montelione, G.T. and Hunt, J.F. (2003). „The 2.3-Å crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase”. J. Biol. Chem. 278: 19176—19182. PMID 12624088.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Quinate/shikimate+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
