Hormon-senzitivna lipaza

Из Википедије, слободне енциклопедије
Hormon-senzitivna lipaza
Identifikatori
EC broj 3.1.1.79
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

Hormon-senzitivna lipaza (EC 3.1.1.79, HSL) je enzim sa sistematskim imenom diacilglicerol acilhidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) diacilglicerol + H2O monoacilglicerol + karboksilat
(2) triacilglicerol + H2O diacilglicerol + karboksilat
(3) monoacilglicerol + H2O glicerol + karboksilat

Ovaj enzim je serinska hidrolaza.

Reference[уреди]

  1. Holm, C., Osterlund, T., Laurell, H. and Contreras, J.A. (2000). „Molecular mechanisms regulating hormone-sensitive lipase and lipolysis”. Annu. Rev. Nutr. 20: 365—393. PMID 10940339. 
  2. Fredrikson, G., Stralfors, P., Nilsson, N.O. and Belfrage, P. (1981). „Hormone-sensitive lipase of rat adipose tissue. Purification and some properties”. J. Biol. Chem. 256: 6311—6320. PMID 7240206. 
  3. Vaughan, M., Berger, J.E. and Steinberg, D. (1964). „Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue”. J. Biol. Chem. 239: 401—409. PMID 14169138. 
  4. Østerlund, T., Danielsson, B., Degerman, E., Contreras, J.A., Edgren, G., Davis, R.C., Schotz, M.C. and Holm, C. (1996). „Domain-structure analysis of recombinant rat hormone-sensitive lipase”. Biochem. J. 319 ( Pt 2): 411—420. PMID 8912675. 
  5. Lee, F.T., Adams, J.B., Garton, A.J. and Yeaman, S.J. (1988). „Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones”. Biochim. Biophys. Acta. 963: 258—264. PMID 3196730. 
  6. Wei, S., Lai, K., Patel, S., Piantedosi, R., Shen, H., Colantuoni, V., Kraemer, F.B. and Blaner, W.S. (1977). „Retinyl ester hydrolysis and retinol efflux from BFC-1β adipocytes”. J. Biol. Chem. 272: 14159—14165. PMID 9162045. 
  7. Tsujita, T., Ninomiya, H. and Okuda, H. (1989). „p-Nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue”. J. Lipid Res. 30: 997—1004. PMID 2794798. 
  8. Yeaman, S.J. (2004). „Hormone-sensitive lipase - new roles for an old enzyme”. Biochem. J. 379: 11—22. PMID 14725507. 

Literatura[уреди]

Spoljašnje vezе[уреди]