Inducibilni faktor hipoksije-asparagin dioksigenaza
| Inducibilni faktor hipoksije-asparagin dioksigenaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 1.14.11.30 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Inducibilni faktor hipoksije-asparagin dioksigenaza (EC 1.14.11.30, HIF hidroksilaza) je enzim sa sistematskim imenom inducibilni faktor hipoksije-L-asparagin, 2-oksoglutarat:kiseonik oksidoreduktaza (4-hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- inducibilni faktor hipoksije-L-asparagin + 2-oksoglutarat + O2 inducibilni faktor hipoksije-(3S)-3-hidroksi-L-asparagin + sukcinat + CO2
Ovaj enzim sadrži gvožđe. Za njegov rad je neophodan askorbat. On katalizuje hidroksilaciju asparagina u C-terminalnom aktivacionom domenu HIF-alfa.
Reference[уреди | уреди извор]
- ^ Mahon, P.C., Hirota, K. and Semenza, G.L. (2001). „FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity”. Genes Dev. 15: 2675—2686. PMID 11641274.
- ^ Hewitson, K.S., McNeill, L.A., Riordan, M.V., Tian, Y.M., Bullock, A.N., Welford, R.W., Elkins, J.M., Oldham, N.J., Bhattacharya, S., Gleadle, J.M., Ratcliffe, P.J., Pugh, C.W. and Schofield, C.J. (2002). „Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family”. J. Biol. Chem. 277: 26351—26355. PMID 12042299.
- ^ Dann, C.E., 3rd, Bruick, R.K. and Deisenhofer, J. (2002). „Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway”. Proc. Natl. Acad. Sci. USA. 99: 15351—15356. PMID 12432100.
- ^ Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J. and Whitelaw, M.L. (2002). „Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch”. Science. 295: 858—861. PMID 11823643.
- ^ Koivunen, P., Hirsila, M., Gunzler, V., Kivirikko, K.I. and Myllyharju, J. (2004). „Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases”. J. Biol. Chem. 279: 9899—9904. PMID 14701857.
- ^ Elkins, J.M., Hewitson, K.S., McNeill, L.A., Seibel, J.F., Schlemminger, I., Pugh, C.W., Ratcliffe, P.J. and Schofield, C.J. (2003). „Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 α”. J. Biol. Chem. 278: 1802—1806. PMID 12446723.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Hypoxia-inducible+factor-asparagine+dioxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
