Izopenicilin-N epimeraza
| Izopenicilin-N epimeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.1.1.17 | ||||||||
| CAS broj | 88201-43-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Izopenicilin-N epimeraza (EC 5.1.1.17, Isopenicillin-N epimerase) je enzim sa sistematskim imenom penicilin-N 5-amino-5-karboksipentanoil-epimeraza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- izopenicilin N penicilin N
Ovaj enzim sadrži piridoksal fosfat.
Reference[уреди | уреди извор]
- ^ Usui, S. & Yu, C.-A. (1989). „Purification and properties of isopenicillin-N epimerase from Streptomyces clavuligerus”. Biochim. Biophys. Acta. 999: 78—85. PMID 2804141.
- ^ Laiz, L., Liras, P., Castro, J.M. and Martín, J.F. (1990). „Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans”. J. Gen. Microbiol. 136: 663—671.
- ^ Cantwell, C., Beckmann, R., Whiteman, P., Queener, S.W. and Abraham, E.P. (1992). „Isolation of deacetoxycephalosporin-c from fermentation broths of Penicillium chrysogenum transformants - construction of a new fungal biosynthetic-pathway”. Proc. R. Soc. Lond. B Biol. Sci. 248: 283—289. PMID 1354366.
- ^ Yeh, W.K., Ghag, S.K. and Queener, S.W. (1992). „Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3′-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering”. Ann. N.Y. Acad. Sci. 672: 396—408.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Isopenicillin-N+epimerase на US National Library of Medicine Medical Subject Headings (MeSH)
