M7GpppX difosfataza
| M7GpppX difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.59 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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M7GpppX difosfataza (EC 3.6.1.59, DcpS, m7GpppX pirofosfataza, m7GpppN m7GMP fosfohidrolaza) je enzim sa sistematskim imenom m7G5'ppp5'N m7GMP fosfohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) m7G5'ppp5'N(3'ppp5'N)n + H2O 7-metilguanozin 5'-fosfat + pp5'N(3'ppp5'N)n
- (2) 7-metilguanozin 5'-difosfat + H2O 7-metilguanozin 5'-fosfat + fosfat
Ovaj enzim posreduje uklanjanje kape i import tokom eukariotske iRNK degradacije.
Reference[уреди | уреди извор]
- ^ Malys, N. & McCarthy, J.E. (2006). „Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies”. J. Mol. Biol. 363: 370—382. PMID 16963086.
- ^ Liu, S.W., Rajagopal, V., Patel, S.S. and Kiledjian, M. (2008). „Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme”. J. Biol. Chem. 283: 16427—16436. PMID 18441014.
- ^ Liu, H., Rodgers, N.D., Jiao, X. and Kiledjian, M. (2002). „The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases”. EMBO J. 21: 4699—4708. PMID 12198172.
- ^ van Dijk, E., Le Hir, H. and Seraphin, B. (2003). „DcpS can act in the 5′-3′ mRNA decay pathway in addition to the 3′-5′ pathway”. Proc. Natl. Acad. Sci. USA. 100: 12081—12086. PMID 14523240.
- ^ Chen, N., Walsh, M.A., Liu, Y., Parker, R. and Song, H. (2005). „Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping”. J. Mol. Biol. 347: 707—718. PMID 15769464.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- M7GpppX+diphosphatase на US National Library of Medicine Medical Subject Headings (MeSH)
