Matična kiselina

Matična kiselina
Nazivi
	IUPAC naziv (E)-10-Hidroksidek-2-enoinska kiselina
	Drugi nazivi 10-Hidroksi-2-decenoinska kiselina; Kiselina matičnog mleča
Identifikacija
CAS broj	14113-05-4;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:78668;
ChemSpider	4472163;
MeSH	C055543
PubChem C ID	5312738;
	SMILES C(CCC/C=C/C(=O)O)CCCO; ; ; ; ; ;
Svojstva
Hemijska formula	C10H18O3
Molarna masa	186,25 g·mol−1
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

Matična kiselina (10-hidroksi-2-decenoinska kiselina) ili 10-HDA je bioaktivno jedinjenje črisutno u matičnom mleču. ^[3]^[4]^[5]^[6]

Kiselina matičnog mleča se istražuje zbog svog farmakološkog dejstva. Postoje indikacije da ona promoviše neurogenezu neuralnih matični/progenitorskih ćelija (ćelija koje imaju sposobnost diferencijacije u neurone, astrocite, ili oligodendrocite) in vitro i koje mogu da budu efektivan metod tretiranja i sprečavanja neuroloških poremećaja.^[7]

Osim toga, poznato je da kiselina matičnog mleča ima antitumorna, antibiotička, imunomodulatorna, estrogenska, neurogena dejstva, kao i da modulira unutrašnje imunske response.^[8]

Vidi još[уреди | уреди извор]

10-Hidroksidekanoinska kiselina

Reference[уреди | уреди извор]

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Bian, M. T. [Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography]. Chung Yao Tung Pao. 12(6):41-43, 1987.
^ Bloodworth, BC; Harn, CS; Hock, CT; Boon, YO (1995). „Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly.” (PDF). Journal of AOAC International. 78 (4): 1019—23. PMID 7580313.
^ Genç, Mahmut; Aslan, Abdurrahman. „Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography”. Journal of Chromatography A. 839 (1-2): 265—268. PMID 10327631. doi:10.1016/S0021-9673(99)00151-X.
^ Ji, N; Yu, RG; Yang, QH; Yu, PH; Li, Y (1987). „[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography].”. Zhong yao tong bao (Beijing, China : 1981). 12 (9): 28—31, 62. PMID 3449246.
^ Hattori, Noriko; Nomoto, Hiroshi; Fukumitsu, Hidefumi; Mishima, Satoshi; Furukawa, Shoei (2007-01-01). „Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro”. Biomedical Research. 28 (5): 261—266. doi:10.2220/biomedres.28.261.
^ „Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses”. doi:10.2174/187153012803832530#sthash.lrbba94a.dpuf.

Spoljašnje veze[уреди | уреди извор]

10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Bian, M. T. [Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography]. Chung Yao Tung Pao. 12(6):41-43, 1987.

[4] Bloodworth, BC; Harn, CS; Hock, CT; Boon, YO (1995). „Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly.” (PDF). Journal of AOAC International. 78 (4): 1019—23. PMID 7580313.

[5] Genç, Mahmut; Aslan, Abdurrahman. „Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography”. Journal of Chromatography A. 839 (1-2): 265—268. PMID 10327631. doi:10.1016/S0021-9673(99)00151-X.

[6] Ji, N; Yu, RG; Yang, QH; Yu, PH; Li, Y (1987). „[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography].”. Zhong yao tong bao (Beijing, China : 1981). 12 (9): 28—31, 62. PMID 3449246.

[7] Hattori, Noriko; Nomoto, Hiroshi; Fukumitsu, Hidefumi; Mishima, Satoshi; Furukawa, Shoei (2007-01-01). „Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro”. Biomedical Research. 28 (5): 261—266. doi:10.2220/biomedres.28.261.

[8] „Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses”. doi:10.2174/187153012803832530#sthash.lrbba94a.dpuf.

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