Matriptaza
| Matriptaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.109 | ||||||||
| CAS broj | 241475-96-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Matriptaza (EC 3.4.21.109, serinska proteaza 14, membranski-tip serinske proteaza 1, MT-SP1, prostamin, serinska proteaza TADG-15, diferencijalno izraženi protein gena 15 asociran sa tumorom, ST14, proteaza raka dojke 80 kDa, epitin, serinska endopeptidaza SNC19) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Presecanje raznih sintetičkih supstrata sa Arg ili Lys u P1 poziciji i sa preferencijom za aminokiseline sa malim bočnim lancima (Ala i Gly) u P2 poziciji
Ova tripsin-slična integralno-membranska serinska peptidaza učestvuje u razvoju i metastazi raka dojke.
Reference[уреди | уреди извор]
- ^ Lee, S.L., Dickson, R.B. and Lin, C.Y. (2000). „Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease”. J. Biol. Chem. 275: 36720—36725. PMID 10962009.
- ^ Lin, C.Y., Anders, J., Johnson, M., Sang, Q.A. and Dickson, R.B. (1999). „Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity”. J. Biol. Chem. 274: 18231—18236. PMID 10373424.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Matriptase на US National Library of Medicine Medical Subject Headings (MeSH)
