N-acetilfosfatidiletanolamin-hidrolizujuća fosfolipaza D
| N-acetilfosfatidiletanolamin-hidrolizujuća fosfolipaza D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.54 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-acetilfosfatidiletanolamin-hidrolizujuća fosfolipaza D (EC 3.1.4.54, NAPE-PLD, anandamid-generišuća fosfolipaza D, N-acil fosfatidiletanolaminska fosfolipaza D, NAPE-hidrolizujuća fosfolipaza D) je enzim sa sistematskim imenom N-acetilfosfatidiletanolamin fosfatidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N-acilfosfatidileetanolamin + H2O N-aciletanolamin + 1,2-diacilglicerol 3-fosfat
Ovaj enzim učestvujeu u biosintezi anandamida.
Reference[уреди | уреди извор]
- ^ Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N. (2004). „Molecular characterization of a phospholipase D generating anandamide and its congeners”. J. Biol. Chem. 279: 5298—5305. PMID 14634025.
- ^ Wang, J., Okamoto, Y., Morishita, J., Tsuboi, K., Miyatake, A. and Ueda, N. (2006). „Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family”. J. Biol. Chem. 281: 12325—12335. PMID 16527816.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- N-acetylphosphatidylethanolamine-hydrolysing+phospholipase+D на US National Library of Medicine Medical Subject Headings (MeSH)
