N6-Metiladenozin

Из Википедије, слободне енциклопедије
N6-Metiladenozin
IUPAC ime
Drugi nazivi m6A
Identifikacija
CAS registarski broj 60209-41-8
PubChem[1][2] 102175
ChemSpider[3] 92307
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C11H15N5O4
Molarna masa 281.27 g mol−1



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

N6-Metiladenozin (m6A ) je često prisutan u iRNK i prisutan je u nekim virusima,[4][5] i većini eukariota uključujući sisare,[6][7][8][9] insekte,[10] biljke[11][12][13] i kvasce.[14][15] On je takoše nađen u tRNK, rRNK, i snRNK kao i u nekoliko dugo kodirajućih RNK, poput Xist.[16][17]

Reference[уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform. 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Beemon K, Keith J (1977). „Localization of N6-methyladenosine in the Rous sarcoma virus genome”. J. Mol. Biol. 113 (1): 165—79. doi:10.1016/0022-2836(77)90047-X. PMID 196091. 
  5. Aloni Y, Dhar R, Khoury G (1979). „Methylation of nuclear simian virus 40 RNAs”. J. Virol. 32 (1): 52—60. PMC 353526слободно за читање. PMID 232187. 
  6. Desrosiers R, Friderici K, Rottman F (1974). „Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells”. Proc. Natl. Acad. Sci. U.S.A. 71 (10): 3971—5. doi:10.1073/pnas.71.10.3971. PMC 434308слободно за читање. PMID 4372599. 
  7. Adams JM, Cory S (1975). „Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA”. Nature. 255 (5503): 28—33. doi:10.1038/255028a0. PMID 1128665. 
  8. Wei CM, Gershowitz A, Moss B (1976). „5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA”. Biochemistry. 15 (2): 397—401. doi:10.1021/bi00647a024. PMID 174715. 
  9. Perry RP, Kelley DE, Friderici K, Rottman F (1975). „The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus”. Cell. 4 (4): 387—94. doi:10.1016/0092-8674(75)90159-2. PMID 1168101. 
  10. Levis R, Penman S (1978). „5'-terminal structures of poly(A)+ cytoplasmic messenger RNA and of poly(A)+ and poly(A)- heterogeneous nuclear RNA of cells of the dipteran Drosophila melanogaster”. J. Mol. Biol. 120 (4): 487—515. doi:10.1016/0022-2836(78)90350-9. PMID 418182. 
  11. Nichols JL (1979). „In maize poly(A)-containing RNA”. Plant Science Letters. 15 (4): 357. doi:10.1016/0304-4211(79)90141-X. 
  12. Kennedy TD, Lane BG (1979). „Wheat embryo ribonucleates. XIII. Methyl-substituted nucleoside constituents and 5'-terminal dinucleotide sequences in bulk poly(AR)-rich RNA from imbibing wheat embryos”. Can. J. Biochem. 57 (6): 927—31. doi:10.1139/o79-112. PMID 476526. 
  13. Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M, Fray RG (2008). „MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor”. Plant Cell. 20 (5): 1278—88. doi:10.1105/tpc.108.058883. PMC 2438467слободно за читање. PMID 18505803. 
  14. Clancy MJ, Shambaugh ME, Timpte CS, Bokar JA (2002). „Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene”. Nucleic Acids Res. 30 (20): 4509—18. doi:10.1093/nar/gkf573. PMC 137137слободно за читање. PMID 12384598. 
  15. Bodi Z, Button JD, Grierson D, Fray RG (2010). „Yeast targets for mRNA methylation”. Nucleic Acids Res. 38 (16): 5327—35. doi:10.1093/nar/gkq266. PMC 2938207слободно за читање. PMID 20421205. 
  16. Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR (2012). „Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3' UTRs and near Stop Codons”. Cell. 149 (7): 1635—46. doi:10.1016/j.cell.2012.05.003. PMID 22608085. 
  17. Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G (2012). „Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq”. Nature. 485 (7397): 201—6. doi:10.1038/nature11112. PMID 22575960. 

Spoljašnje veze[уреди]