NRP2
| Neuropilin 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||
| Dostupne strukture | |||||||||||
| 2QQJ, 2QQK, 2QQL, 2QQO | |||||||||||
| Identifikatori | |||||||||||
| Simboli | NRP2; NP2; NPN2; PRO2714; VEGF165R2 | ||||||||||
| Vanjski ID | OMIM: 602070 MGI: 1100492 HomoloGene: 2875 GeneCards: NRP2 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8828 | 18187 | |||||||||
| Ensembl | ENSG00000118257 | ENSMUSG00000025969 | |||||||||
| UniProt | O60462 | O35375 | |||||||||
| RefSeq (mRNA) | NM_003872.2 | NM_001077403.1 | |||||||||
| RefSeq (protein) | NP_003863.2 | NP_001070871.1 | |||||||||
| Lokacija (UCSC) |
Chr 2: 206.55 - 206.66 Mb |
Chr 1: 62.7 - 62.82 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Neuropilin-2 je protein koji je kod ljudi kodiran NRP2 genom.[1][2]
Ovaj protein je član neuropilinske familije receptora. On je transmembranski protein koji se vezuje za SEMA3C protein (sema domen, imunoglobulinski domen (Ig), kratki bazni domen) i SEMA3F protein. On formira interakciju sa vaskularnim endotelnim faktorom rasta (VEGF). Ovaj protein učestvuje u kardiovaskularnom razvoju, navođenu aksona, i tumorigenezi. Višestruke transkriptne varijante koje kodiraju različite izoforme su poznate.[3]
Reference[уреди | уреди извор]
- ^ Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (1998). „Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor”. Cell. 92 (6): 735—45. PMID 9529250. doi:10.1016/S0092-8674(00)81402-6.
- ^ Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (1997). „Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III”. Neuron. 19 (3): 547—59. PMID 9331348. doi:10.1016/S0896-6273(00)80371-2.
- ^ „Entrez Gene: NRP2 neuropilin 2”.
Literatura[уреди | уреди извор]
- Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). „Vascular endothelial growth factor (VEGF) and its receptors.”. FASEB J. 13 (1): 9—22. PMID 9872925.
- Kolodkin AL; Levengood DV; Rowe EG; et al. (1997). „Neuropilin is a semaphorin III receptor.”. Cell. 90 (4): 753—62. PMID 9288754. doi:10.1016/S0092-8674(00)80535-8.
- Giger RJ; Urquhart ER; Gillespie SK; et al. (1999). „Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.”. Neuron. 21 (5): 1079—92. PMID 9856463. doi:10.1016/S0896-6273(00)80625-X.
- Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). „Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.”. Neuron. 21 (6): 1283—90. PMID 9883722. doi:10.1016/S0896-6273(00)80648-0.
- Takahashi T; Nakamura F; Jin Z; et al. (1999). „Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.”. Nat. Neurosci. 1 (6): 487—93. PMID 10196546. doi:10.1038/2203.
- Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). „Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.”. Genomics. 57 (3): 459—60. PMID 10329017. doi:10.1006/geno.1999.5790.
- Tamagnone L; Artigiani S; Chen H; et al. (1999). „Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.”. Cell. 99 (1): 71—80. PMID 10520995. doi:10.1016/S0092-8674(00)80063-X.
- Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). „Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected].”. J. Biol. Chem. 275 (24): 18040—5. PMID 10748121. doi:10.1074/jbc.M909259199.
- Handa A; Tokunaga T; Tsuchida T; et al. (2000). „Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.”. Int. J. Oncol. 17 (2): 291—5. PMID 10891538.
- Rossignol M, Gagnon ML, Klagsbrun M (2001). „Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.”. Genomics. 70 (2): 211—22. PMID 11112349. doi:10.1006/geno.2000.6381.
- Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). „Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes.”. J. Biol. Chem. 276 (22): 18688—94. PMID 11278319. doi:10.1074/jbc.M006909200.
- Cohen T; Gluzman-Poltorak Z; Brodzky A; et al. (2001). „Neuroendocrine cells along the digestive tract express neuropilin-2.”. Biochem. Biophys. Res. Commun. 284 (2): 395—403. PMID 11394892. doi:10.1006/bbrc.2001.4958.
- Herzog Y; Kalcheim C; Kahane N; et al. (2002). „Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins.”. Mech. Dev. 109 (1): 115—9. PMID 11677062. doi:10.1016/S0925-4773(01)00518-4.
- Oh H; Takagi H; Otani A; et al. (2002). „Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis.”. Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383—8. PMC 117569
. PMID 11756651. doi:10.1073/pnas.012074399. - Fakhari M; Pullirsch D; Abraham D; et al. (2002). „Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma.”. Cancer. 94 (1): 258—63. PMID 11815985. doi:10.1002/cncr.10177.
- Cohen T; Herzog Y; Brodzky A; et al. (2002). „Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours.”. J. Pathol. 198 (1): 77—82. PMID 12210066. doi:10.1002/path.1179.
- Kawakami T; Tokunaga T; Hatanaka H; et al. (2003). „Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma.”. Cancer. 95 (10): 2196—201. PMID 12412174. doi:10.1002/cncr.10936.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
