PPP1R9B

Из Википедије, слободне енциклопедије
Protein fosfataza 1, regulatorna podjedinica 9B

PDB prikaz baziran na 2g5m.
Identifikatori
Simboli PPP1R9B; PPP1R6; PPP1R9; SPINO; Spn
Vanjski ID OMIM603325 MGI2387581 HomoloGene32787 GeneCards: PPP1R9B Gene
Pregled RNK izražavanja
PBB GE PPP1R9B gnf1h00838 at tn.png
PBB GE PPP1R9B gnf1h00839 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 84687 217124
Ensembl ENSG00000108819 ENSMUSG00000038976
UniProt Q96SB3 Q6R891
RefSeq (mRNA) NM_032595.3 NM_172261.3
RefSeq (protein) NP_115984.3 NP_758465.2
Lokacija (UCSC) Chr 17:
45.57 - 45.58 Mb
Chr 11:
94.85 - 94.87 Mb
PubMed pretraga [1] [2]

Neurabin-2 je protein koji je kod ljudi kodiran PPP1R9B genom.[1][2]

Spinofilin je regulatorni deo katalitičke jedinica proteinske fosfataze-1 (PP1). On je visoko izražen u dendritskim izbočinama, specijalizoanim delovima koji primaju veći deo ekscitatornog unosa u centralnom nervnom sistemu.[2]

Interakcije[уреди]

PPP1R9B formira interakcije sa PPP1CB,[3] PPP1CA,[3] Dopamine receptor D2,[4] P16,[5] PPP1CC,[3][4] TIAM1[6] i PPP1R2.[7]

Reference[уреди]

  1. ^ Allen PB, Ouimet CC, Greengard P (Oct 1997). „Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines“. Proc Natl Acad Sci U S A 94 (18): 9956–61. DOI:10.1073/pnas.94.18.9956. PMC 23308. PMID 9275233. 
  2. ^ а б „Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B“. 
  3. ^ а б в Hsieh-Wilson, L C; Allen P B, Watanabe T, Nairn A C, Greengard P (Apr. 1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1“. Biochemistry (UNITED STATES) 38 (14): 4365–73. DOI:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355. 
  4. ^ а б Smith, F D; Oxford G S, Milgram S L (Jul. 1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein“. J. Biol. Chem. (UNITED STATES) 274 (28): 19894–900. DOI:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935. 
  5. ^ Vivo, M; Calogero R A, Sansone F, Calabrò V, Parisi T, Borrelli L, Saviozzi S, La Mantia G (Apr. 2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein“. J. Biol. Chem. (United States) 276 (17): 14161–9. DOI:10.1074/jbc.M006845200. ISSN 0021-9258. PMID 11278317. 
  6. ^ Buchsbaum, Rachel J; Connolly Beth A, Feig Larry A (May. 2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin“. J. Biol. Chem. (United States) 278 (21): 18833–41. DOI:10.1074/jbc.M207876200. ISSN 0021-9258. PMID 12531897. 
  7. ^ Terry-Lorenzo, Ryan T; Elliot Elizabeth, Weiser Douglas C, Prickett Todd D, Brautigan David L, Shenolikar Shirish (Nov. 2002). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton“. J. Biol. Chem. (United States) 277 (48): 46535–43. DOI:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929. 

Literatura[уреди]