Precorin-3B sintaza
| Precorin-3B sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.83 | ||||||||
| CAS broj | 152787-63-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Precorin-3B sintaza (EC 1.14.13.83, prekorin-3X sintaza, CobG) je enzim sa sistematskim imenom prekorin-3A,NADH:kiseonik oksidoreduktaza (20-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- prekorin-3A + NADH + H+ + O2 prekorin-3B + NAD+ + H2O
Ovaj enzim je gvožđe-sumporni protein. Kiseonični atom se inkorporira u makrociklus na C-20.
Reference[уреди | уреди извор]
- ^ Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F. (1993). „Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans”. J. Bacteriol. 175: 7430—7440. PMID 8226690.
- ^ Scott, A.I., Roessner, C.A., Stolowich, N.J., Spencer, J.B., Min, C. and Ozaki, S.I. (1993). „Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group”. FEBS Lett. 331: 105—108. PMID 8405386.
- ^ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390—412. PMID 12195810.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Precorrin-3B+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
