2,7,4'-Trihidroksiizoflavanon 4'-O-metiltransferaza
| 2,7,4'-Trihidroksiizoflavanon 4'-O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.212 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2,7,4'-Trihidroksiizoflavanon 4'-O-metiltransferaza (EC 2.1.1.212, SAM:2,7,4'-trihidroksiizoflavanonska 4'-O-metiltransferaza, HI4'OMT, HMM1, MtIOMT5) je enzim sa sistematskim imenom S-adenozil-L-metionin:2,7,4'-trihidroksiizoflavanon 4'-O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + 2,7,4'-trihidroksiizoflavanon S-adenozil-L-homocistein + 2,7-dihidroksi-4'-metoksiizoflavanon
Ovaj enzim specifično metiluje 2,7,4'-trihidroksiizoflavanon u 4'-poziciji. On ne deluje na izoflavone. Enzim učestvuje u biosintezi formononetina .
Reference[уреди | уреди извор]
- ^ Akashi, T., Sawada, Y., Shimada, N., Sakurai, N., Aoki, T. and Ayabe, S. (2003). „cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway”. Plant Cell Physiol. 44: 103—112. PMID 12610212.
- ^ Deavours, B.E., Liu, C.J., Naoumkina, M.A., Tang, Y., Farag, M.A., Sumner, L.W., Noel, J.P. and Dixon, R.A. (2006). „Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula”. Plant Mol. Biol. 62: 715—733. PMID 17001495.
- ^ Liu, C.J., Deavours, B.E., Richard, S.B., Ferrer, J.L., Blount, J.W., Huhman, D., Dixon, R.A. and Noel, J.P. (2006). „Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses”. Plant Cell. 18: 3656—3669. PMID 17172354.
- ^ Akashi, T., VanEtten, H.D., Sawada, Y., Wasmann, C.C., Uchiyama, H. and Ayabe, S. (2006). „Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis”. Phytochemistry. 67: 2525—2530.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 2,7,4'-trihydroxyisoflavanone+4'-O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
