Sklareolna ciklaza
| Sklareolna ciklaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.7.4 | ||||||||
| CAS broj | 146838-18-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sklareolna ciklaza (EC 3.1.7.4, geranilgeranil pirofosfat:sklareol ciklaza, geranilgeranil pirofosfat-sklareol ciklaza, GGPP:sklareol ciklaza) je enzim sa sistematskim imenom geranilgeranil-difosfat difosfohidrolaza (formira sklareol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za dejstvo ovog enzima je neophodan jon Mg2+ ili Mn2+.
Reference[уреди | уреди извор]
- ^ Banthorpe, D.V., Brown, J.T. and Morris, G.S. (1992). „Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material”. Phytochemistry. 31: 3391—3395.
- ^ Dimas, K., Hatziantoniou, S., Tseleni, S., Khan, H., Georgopoulos, A., Alevizopoulos, K., Wyche, J.H., Pantazis, P. and Demetzos, C. (2007). „Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice”. Apoptosis. 12: 685—694. PMID 17260186.
- ^ Guo, Z. & Wagner, G.J. (1995). „Biosynthesis of labdenediol and sclareol in cell-free extracts from trichomes of Nicotiana glutinosa”. Planta. 197: 627—632.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Sclareol+cyclase на US National Library of Medicine Medical Subject Headings (MeSH)
