TRNK pseudouridinska13 sintaza

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TRNK pseudouridinska13 sintaza
Identifikatori
EC broj 5.4.99.27
CAS broj 430429-15-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

TRNK pseudouridinska13 sintaza (EC 5.4.99.27, TruD, YgbO, tRNK PSI13 sintaza, RNK:PSI-sintaza Pus7p, Pus7p, RNK:pseudouridin-sintaza Pus7p, Pus7 protein) je enzim sa sistematskim imenom tRNK-uridin13 uracil mutaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

tRNK uridin13 \rightleftharpoons tRNK pseudouridin13

Pseudouridinska sintaza TruD iz Escherichia coli specifično deluje na uridin13 u tRNK.

Reference[уреди]

  1. Ericsson, U.B., Nordlund, P. and Hallberg, B.M. (2004). „X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold“. FEBS Lett. 565: 59-64. PMID 15135053. 
  2. Chan, C.M. and Huang, R.H. (2009). „Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases“. Arch. Biochem. Biophys. 489: 15-19. PMID 19664587. 
  3. Kaya, Y. and Ofengand, J. (2003). „A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya“. RNA 9: 711-721. PMID 12756329. 
  4. Behm-Ansmant, I., Urban, A., Ma, X., Yu, Y.T., Motorin, Y. and Branlant, C. (2003). „The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs“. RNA 9: 1371-1382. PMID 14561887. 
  5. Urban, A., Behm-Ansmant, I., Branlant, C. and Motorin, Y. (2009). „RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p“. J. Biol. Chem. 284: 5845-5858. PMID 19114708. 

Literatura[уреди]

Spoljašnje veze[уреди]