TRNK pseudouridinska13 sintaza
| TRNK pseudouridinska13 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.27 | ||||||||
| CAS broj | 430429-15-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK pseudouridinska13 sintaza (EC 5.4.99.27, TruD, YgbO, tRNK PSI13 sintaza, RNK:PSI-sintaza Pus7p, Pus7p, RNK:pseudouridin-sintaza Pus7p, Pus7 protein) je enzim sa sistematskim imenom tRNK-uridin13 uracil mutaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tRNK uridin13 tRNK pseudouridin13
Pseudouridinska sintaza TruD iz Escherichia coli specifično deluje na uridin13 u tRNK.
Reference[уреди | уреди извор]
- ^ Ericsson, U.B., Nordlund, P. and Hallberg, B.M. (2004). „X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold”. FEBS Lett. 565: 59—64. PMID 15135053.
- ^ Chan, C.M. & Huang, R.H. (2009). „Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases”. Arch. Biochem. Biophys. 489: 15—19. PMID 19664587.
- ^ Kaya, Y. & Ofengand, J. (2003). „A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya”. RNA. 9: 711—721. PMID 12756329.
- ^ Behm-Ansmant, I., Urban, A., Ma, X., Yu, Y.T., Motorin, Y. and Branlant, C. (2003). „The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs”. RNA. 9: 1371—1382. PMID 14561887.
- ^ Urban, A., Behm-Ansmant, I., Branlant, C. and Motorin, Y. (2009). „RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p”. J. Biol. Chem. 284: 5845—5858. PMID 19114708.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- TRNA+pseudouridine13+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
