TRNK pseudouridinska13 sintaza

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TRNK pseudouridinska13 sintaza
Identifikatori
EC broj 5.4.99.27
CAS broj 430429-15-5
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

TRNK pseudouridinska13 sintaza (EC 5.4.99.27, TruD, YgbO, tRNK PSI13 sintaza, RNK:PSI-sintaza Pus7p, Pus7p, RNK:pseudouridin-sintaza Pus7p, Pus7 protein) je enzim sa sistematskim imenom tRNK-uridin13 uracil mutaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

tRNK uridin13 tRNK pseudouridin13

Pseudouridinska sintaza TruD iz Escherichia coli specifično deluje na uridin13 u tRNK.

Reference[уреди]

  1. Ericsson, U.B., Nordlund, P. and Hallberg, B.M. (2004). „X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold”. FEBS Lett. 565: 59—64. PMID 15135053. 
  2. Chan, C.M. & Huang, R.H. (2009). „Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases”. Arch. Biochem. Biophys. 489: 15—19. PMID 19664587. 
  3. Kaya, Y. & Ofengand, J. (2003). „A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya”. RNA. 9: 711—721. PMID 12756329. 
  4. Behm-Ansmant, I., Urban, A., Ma, X., Yu, Y.T., Motorin, Y. and Branlant, C. (2003). „The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs”. RNA. 9: 1371—1382. PMID 14561887. 
  5. Urban, A., Behm-Ansmant, I., Branlant, C. and Motorin, Y. (2009). „RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p”. J. Biol. Chem. 284: 5845—5858. PMID 19114708. 

Literatura[уреди]

Spoljašnje veze[уреди]