Vinorin sintaza
| Vinorin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.160 | ||||||||
| CAS broj | 88844-97-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Vinorin sintaza (EC 2.3.1.160) je enzim sa sistematskim imenom acil-KoA:16-epivelozimin O-acetiltransferaza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + 16-epivelozimin KoA + vinorin
Ova reakcija se odvija u dva stupnja.
Reference[уреди | уреди извор]
- ^ Pfitzner, A., Polz, L. and Stöckligt, J. (1986). „Properties of vinorine synthase the Rauwolfia enzyme involved in the formation of the ajmaline skeleton”. Z. Naturforsch. C: Biosci. 41: 103—114.
- ^ Bayer, A., Ma, X. and Stöckigt, J. (2004). „Acetyltransfer in natural product biosynthesis—functional cloning and molecular analysis of vinorine synthase”. Bioorg. Med. Chem. 12: 2787—2795. PMID 15110860.
- ^ Ma, X., Koepke, J., Bayer, A., Linhard, V., Fritzsch, G., Zhang, B., Michel, H. and Stöckigt, J. (2004). „Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily”. Biochim. Biophys. Acta. 1701: 129—132. PMID 15450182.
- ^ Ma, X., Koepke, J., Panjikar, S., Fritzsch, G. and Stöckigt, J. (2005). „Crystal structure of vinorine synthase, the first representative of the BAHD superfamily”. J. Biol. Chem. 280: 13576—13583. PMID 15665331.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Vinorine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
