GNA12

Из Википедије, слободне енциклопедије
Guanin nukleotid-vezujući protein (G protein), alfa 12

PDB prikaz baziran na 1zca.
Dostupne strukture
1zca
Identifikatori
Simboli GNA12; RMP; MGC104623; MGC99644; NNX3; gep
Vanjski ID OMIM604394 MGI95767 HomoloGene22398 GeneCards: GNA12 Gene
Pregled RNK izražavanja
PBB GE GNA12 221737 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2768 14673
Ensembl ENSG00000146535 ENSMUSG00000000149
UniProt Q03113 Q2NKI3
RefSeq (mRNA) NM_007353 XM_001001104
RefSeq (protein) NP_031379 XP_001001104
Lokacija (UCSC) Chr 7:
2.73 - 2.85 Mb
Chr 5:
141.01 - 141.08 Mb
PubMed pretraga [1] [2]

GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.[1][2][3]

Interakcije[уреди]

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,[4] ARHGEF12,[5][6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1[7] i TEC.[6]

Reference[уреди]

  1. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Stuart A. Aaronson (Feb 1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product“. Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800. 
  2. ^ Kumar RN, Shore SK, Dhanasekaran N (Feb 2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3“. Oncogene 25 (6): 899–906. DOI:10.1038/sj.onc.1209132. PMID 16247467. 
  3. ^ „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12“. 
  4. ^ Yamaguchi, Yoshiaki; Katoh Hironori, Mori Kazutoshi, Negishi Manabu (Aug. 2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity“. Curr. Biol. (England) 12 (15): 1353–8. DOI:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367. 
  5. ^ Fukuhara, S; Chikumi H, Gutkind J S (Nov. 2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho“. FEBS Lett. (NETHERLANDS) 485 (2-3): 183–8. DOI:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164. 
  6. ^ а б Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (Jan. 2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF“. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. DOI:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  7. ^ Vaiskunaite, R; Kozasa T, Voyno-Yasenetskaya T A (Dec. 2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling“. J. Biol. Chem. (United States) 276 (49): 46088–93. DOI:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136. 

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