Tripanotion-disulfid reduktaza
| Tripanotion-disulfid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.1.12 | ||||||||
| CAS broj | 102210-35-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Tripanotion-disulfid reduktaza (EC 1.8.1.12, tripanotionska reduktaza, NADPH2:tripanotionska oksidoreduktaza) je enzim sa sistematskim imenom tripanotion:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tripanotion + NADP+ tripanotion disulfid + NADPH + H+
Tripanotion disulfid je oksidovana forma N1,N8-bis(glutationil)-spermidina iz insektnog-parazitskog tripanozomatida Crithidia fasciculata. Enzim iz Crithidia fasciculata je flavoprotein (FAD). Njegovo dejstvo je zavisno od redoks-aktivnog cistina na aktivnom mestu.
Reference[уреди | уреди извор]
- ^ Shames, S.L., Fairlamb, A.H., Cerami, A. and Walsh, C.T. (1986). „Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases”. Biochemistry. 25: 3519—3526. PMID 3718941.
- ^ Marsh, I.R. & Bradley, M. (1977). „Substrate specificity of trypanothione reductase”. Eur. J. Biochem. 243: 690—694. PMID 9057833.
- ^ Cunningham, M.L. & Fairlamb, A.H. (1995). „Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials”. Eur. J. Biochem. 230: 460—468. PMID 7607216.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Trypanothione-disulfide+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
