Фарнезилтрансфераза

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Proteinska farneziltransferaza
Identifikatori
EC broj2.5.1.58
CAS broj131384-38-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum

Farneziltransferaza (EC 2.5.1.58, FTaze) je enzim sa sistematskim imenom farnezil-difosfat:protein-cistein farneziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

farnezil difosfat + protein-cistein S-farnezil protein + difosfat

Ovaj enzim, zajedno sa proteinskom geranilgeraniltransferazom tip I (EC 2.5.1.59) i II (EC 2.5.1.60) sačinjava proteinsku preniltransferaznu familiju enzima.

Reference[уреди]

  1. ^ Furfine, E.S., Leban, J.J., Landavazo, A., Moomaw, J.F. and Casey, P.J. (1995). „Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release”. Biochemistry. 34: 6857—6862. PMID 7756316. 
  2. ^ Casey, P.J. & Seabra, M.C. (1996). „Protein prenyltransferases”. J. Biol. Chem. 271: 5289—5292. PMID 8621375. 
  3. ^ Long, S.B., Casey, P.J. and Beese, L.S. (1998). „Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate”. Biochemistry. 37: 9612—9618. PMID 9657673. 
  4. ^ Micali, E., Chehade, K.A., Isaacs, R.J., Andres, D.A. and Spielmann, H.P. (2001). „Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups”. Biochemistry. 40: 12254—12265. PMID 11591144. 
  5. ^ Long, S.B., Casey, P.J. and Beese, L.S. (2002). „Reaction path of protein farnesyltransferase at atomic resolution”. Nature. 419: 645—650. PMID 12374986. 
  6. ^ Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118. 

Литература[уреди]

  • Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118. 

Spoljašnje veze[уреди]