Farneziltransferaza

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Proteinska farneziltransferaza
Identifikatori
EC broj 2.5.1.58
CAS broj 131384-38-8
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

Farneziltransferaza (EC 2.5.1.58, FTaze) je enzim sa sistematskim imenom farnezil-difosfat:protein-cistein farneziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

farnezil difosfat + protein-cistein S-farnezil protein + difosfat

Ovaj enzim, zajedno sa proteinskom geranilgeraniltransferazom tip I (EC 2.5.1.59) i II (EC 2.5.1.60) sačinjava proteinsku preniltransferaznu familiju enzima.

Reference[уреди]

  1. ^ Furfine, E.S., Leban, J.J., Landavazo, A., Moomaw, J.F. and Casey, P.J. (1995). „Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release”. Biochemistry. 34: 6857—6862. PMID 7756316. 
  2. ^ Casey, P.J. & Seabra, M.C. (1996). „Protein prenyltransferases”. J. Biol. Chem. 271: 5289—5292. PMID 8621375. 
  3. ^ Long, S.B., Casey, P.J. and Beese, L.S. (1998). „Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate”. Biochemistry. 37: 9612—9618. PMID 9657673. 
  4. ^ Micali, E., Chehade, K.A., Isaacs, R.J., Andres, D.A. and Spielmann, H.P. (2001). „Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups”. Biochemistry. 40: 12254—12265. PMID 11591144. 
  5. ^ Long, S.B., Casey, P.J. and Beese, L.S. (2002). „Reaction path of protein farnesyltransferase at atomic resolution”. Nature. 419: 645—650. PMID 12374986. 
  6. ^ Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118. 

Литература[уреди]

  • Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118. 

Spoljašnje veze[уреди]