Рибонуклеаза З
| Ribonukleaza Z | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.26.11 | ||||||||
| CAS broj | 98148-84-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ribonukleaza Z (EC 3.1.26.11, 3 tRNaza, tRNK 3 endonukleaza, RNaza Z, 3' tRNaza) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endonukleolitičko razlaganje RNK, uklanjanje ekstra 3' nukleotida sa tRNK prekursora, generisanje 3' krajeva tRNK molekula
Ovaj enzim ne koristi kofaktor.
Reference[уреди | уреди извор]
- ^ Schiffer, S., Rösch, S. and Marchfelder, A. (2002). „Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes”. EMBO J. 21: 2769—2777. PMID 12032089.
- ^ Mayer, M., Schiffer, S. and Marchfelder, A. (2000). „tRNA 3′ processing in plants: nuclear and mitochondrial activities differ”. Biochemistry. 39: 2096—2105. PMID 10684660.
- ^ Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. (2001). „The plant tRNA 3′ processing enzyme has a broad substrate spectrum”. Biochemistry. 40: 8264—8272. PMID 11444972.
- ^ Kunzmann, A., Brennicke, A. and Marchfelder, A. (1998). „5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria”. Proc. Natl. Acad. Sci. USA. 95: 108—113. PMID 9419337.
- ^ Mörl, M. & Marchfelder, A. (2001). „The final cut. The importance of tRNA 3′-processing”. EMBO Rep. 2: 17—20. PMID 11252717.
- ^ Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. (2004). „A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima”. J. Biol. Chem. 279: 15688—15697. PMID 14749326.
- ^ Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. (2003). „A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease”. Nucleic Acids Res. 31: 2272—2278. PMID 12711671.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
