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Sfingomijelinska deacilaza

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Sfingomijelinska deacilaza
Identifikatori
EC broj3.5.1.109
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Sfingomijelinska deacilaza (EC 3.5.1.109, SM deacilaza, GcSM deacilaza, glukozilkeramid sfingomijelinska deacilaza, sfingomijelin glukozilkeramidna deacilaza, SM glukozilkeramid GCer deacilaza, SM-GCer deacilaza, SMGCer deacilaza) je enzim sa sistematskim imenom N-acil-sfingozilfosforilholin amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) N-acil-sfingozilfosforilholin + H2O masna kiselina + sfingozilfosforilholin;;
(2) D-glukozil-N-acilsfingozin + H2O masna kiselina + D-glukozil-sfingozin

Ovaj enzim učestvuje u sfingolipidnom metabolizmu u epidermisu.

Reference

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  1. ^ Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis”. J. Invest. Dermatol. 115: 406—413. PMID 10951276. 
  2. ^ Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide”. Biochem. J. 350: 747—756. PMID 10970788. 
  3. ^ Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. (2003). „Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis”. Lab. Invest. 83: 397—408. PMID 12649340. 

Literatura

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Spoljašnje veze

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