Acil-homoserin-lakton sintaza
| Acil-homoserin-lakton sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.184 | ||||||||
| CAS broj | 176023-66-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acil-homoserin-lakton sintaza (EC 2.3.1.184, acil-homoserin laktonska sintaza, acil homoserin laktonska sintaza, acil-homoserinlakton sintaza, acilhomoserin laktonska sintaza, AHL sintaza, AHS, AHSL sintaza, AhyI, AinS, AinS protein, autoinducer sintaza, autoinducer sinteza protein rhlI, EsaI, ExpISCC1, ExpISCC3065, LasI, LasR, LuxI, LuxI protein, LuxM, N-acil homoserin lakton sintaza, RhlI, YspI, acil-(acil nosilac protein):S-adenozil-L-metionin aciltranseraza (formira lakton, otpušta metiltioadenozin)) je enzim sa sistematskim imenom acil-(acil-nosilac protein):S-adenozil-L-metionin aciltranseraza (formira lakton).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-[acil-nosilac protein] + S-adenozil-L-metionin [acil-nosilac protein] + S-metil-5'-tioadenozin + N-acil-L-homoserin lakton
Acil-homoserinske laktone formiraju brojne bakterijske vrste. Oni se koriste za regulaciju izražavanja gena virulencije u procesu poznatom kao očitavanje kvoruma.
Reference
[уреди | уреди извор]- ^ Schaefer, A.L., Val, D.L., Hanzelka, B.L., Cronan, J.E., Jr. and Greenberg, E.P. (1996). „Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein”. Proc. Natl. Acad. Sci. USA. 93: 9505—9509. PMID 8790360.
- ^ Watson, W.T., Murphy, F.V., 4th, Gould, T.A., Jambeck, P., Val, D.L., Cronan, J.E., Jr., Beck von Bodman, S. and Churchill, M.E. (2001). „Crystallization and rhenium MAD phasing of the acyl-homoserinelactone synthase EsaI”. Acta Crystallogr. D Biol. Crystallogr. 57: 1945—1949. PMID 11717525.
- ^ Chakrabarti, S. & Sowdhamini, R. (2003). „Functional sites and evolutionary connections of acylhomoserine lactone synthases”. Protein Eng. 16: 271—278. PMID 12736370.
- ^ Hanzelka, B.L., Parsek, M.R., Val, D.L., Dunlap, P.V., Cronan, J.E., Jr. and Greenberg, E.P. (1999). „Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein”. J. Bacteriol. 181: 5766—5770. PMID 10482519.
- ^ Parsek, M.R., Val, D.L., Hanzelka, B.L., Cronan, J.E., Jr. and Greenberg, E.P. (1999). „Acyl homoserine-lactone quorum-sensing signal generation”. Proc. Natl. Acad. Sci. USA. 96: 4360—4365. PMID 10200267.
- ^ Ulrich, R.L. (2004). „Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis”. Appl. Environ. Microbiol. 70: 6173—6180. PMID 15466564.
- ^ Gould, T.A., Schweizer, H.P. and Churchill, M.E. (2004). „Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI”. Mol. Microbiol. 53: 1135—1146. PMID 15306017.
- ^ Raychaudhuri, A., Jerga, A. and Tipton, P.A. (2005). „Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa”. Biochemistry. 44: 2974—2981. PMID 15723540.
- ^ Gould, T.A., Herman, J., Krank, J., Murphy, R.C. and Churchill, M.E. (2006). „Specificity of acyl-homoserine lactone synthases examined by mass spectrometry”. J. Bacteriol. 188: 773—783. PMID 16385066.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Acyl-homoserine-lactone+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
