Naftalen 1,2-dioksigenaza
| Naftalen 1,2-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.12 | ||||||||
| CAS broj | 2620349 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Naftalen 1,2-dioksigenaza (EC 1.14.12.12, naftalenska dioksigenaza, naftalenska oksigenaza, NDO) je enzim sa sistematskim imenom naftalen,NADH:kiseonik oksidoreduktaza (1,2-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- naftalen + NADH + H+ + O2 (1R,2S)-1,2-dihidronaftalen-1,2-diol + NAD+
Ovaj enzim je član familije dioksigenaza koji vrše hidroksilaciju prstena. Ovi bakterijski enzimi imaju kritičnu ulogu u degradaciji aromatičnih jedinjenja.
Reference[уреди | уреди извор]
- ^ Ensley, B.D. & Gibson, D.T. (1983). „Naphthalene dioxygenase: purification and properties of a terminal oxygenase component”. J. Bacteriol. 155: 505—511. PMID 6874638.
- ^ Jeffrey, A.M., Yeh, H.J.C., Jerina, D.M., Patel, T.R., Davey, J.F. and Gibson, D.T. (1975). „Initial reactions in the oxidation of naphthalene by Pseudomonas putida”. Biochemistry. 14: 575—584. PMID 234247.
- ^ Kauppi, B., Lee, K., Carredano, E., Parales, R.E., Gibson, D.T., Eklund, H. and Ramaswamy, S. (1998). „Structure of an aromatic-ring-hydroxylating dioxygenase - naphthalene 1,2-dioxygenase”. Structure. 6: 571—586. PMID 9634695.
- ^ Parales, R.E., Lee, K., Resnick, S.M., Jiang, H., Lessner, D.J. and Gibson, D.T. (2000). „Substrate specificity of naphthalene dioxygenase: effect of specific amino acids at the active site of the enzyme”. J. Bacteriol. 182: 1641—1649. PMID 10692370.
- ^ Jouanneau, Y., Meyer, C., Jakoncic, J., Stojanoff, V. and Gaillard, J. (2006). „Characterization of a naphthalene dioxygenase endowed with an exceptionally broad substrate specificity toward polycyclic aromatic hydrocarbons”. Biochemistry. 45: 12380—12391. PMID 17014090.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Naphthalene+1,2-dioxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
