Tiopurin S-metiltransferaza
| Tiopurin S-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.1.1.67 | ||||||||
| CAS broj | 67339-09-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Tiopurin S-metiltransferaza (EC 2.1.1.67, merkaptopurinska metiltransferaza, tiopurinska metiltransferaza, 6-tiopurinska transmetilaza, TPMT) je enzim sa sistematskim imenom S-adenozil-L-metionin:tiopurin S-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + tiopurin S-adenozil-L-homocistein + tiopurin S-metilther
Ovaj enzim takođe u izvesnoj meri deluje na tiopirimidine i aromatične tiole. On nije identičan sa EC 2.1.1.9, tiol S-metiltransferazom.
Reference[уреди | уреди извор]
- ^ Remy, C.N. (1963). „Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues”. J. Biol. Chem. 238: 1078—1084. PMID 13981612.
- ^ Woodson, L.C., Ames, M.M., Selassie, C.D, Hansch, C. and Weinshilbaum, R.M. (1983). „Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives”. Mol. Pharmacol. 24: 471—478. PMID 6633508.
- ^ Woodson, L.C. & Weinshilbaum, R.M. (1983). „Human kidney thiopurine methyltransferase. Purification and biochemical properties”. Biochem. Pharmacol. 32: 819—826. PMID 6838629.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Thiopurine+S-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
