(Heparan sulfat)-glukozamin 3-sulfotransferaza 3
(преусмерено са (heparan sulfat)-glukozamin 3-sulfotransferaza 3)
| (heparan sulfat)-glukozamin 3-sulfotransferaza 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.30 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(heparan sulfat)-glukozamin 3-sulfotransferaza 3 (EC 2.8.2.30, (heparan sulfate)-glucosamine 3-sulfotransferase 3) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin 3-sulfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-glukozamin 3-sulfat
Dva glavna supstrata sadrže tetrasaharide: -> neodređena 2-sulfo-uronska kiselina -> GlcN2S-> IdoA2S-> GlcN* -> i -> neodređena 2-sulfo-uronska kiselina -> GlcN2S-> IdoA2S-> GlcN6S* ->.
Reference[уреди | уреди извор]
- ^ Liu, J., Shriver, Z., Blaiklock, P., Yoshida, K., Sasisekharan, R. and Rosenberg, R.D. (1999). „Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A sulfates N-unsubstituted glucosamine”. J. Biol. Chem. 274: 38155—38162. PMID 10608887.
- ^ Shukla, D., Liu, J., Blaiklock, P., Shworak, N.W., Bai, X., Esko, J.D., Cohen, G.H., Eisenberg, R.J., Rosenberg, R.D. and Spear, P.G. (1999). „A novel role for 3-O-sulfated heparan sulfate in Herpes simplex virus 1 entry”. Cell. 99: 13—22. PMID 10520990.
- ^ Shworak, N.W., Liu, J., Petros, L.M., Copeland, N.G. (1999). „, Jenkins N.A. and Rosenberg, R.D. Diversity of the extensive heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST) multigene family”. J. Biol. Chem. 274: 5170—5184. PMID 9988767.
- ^ Liu, J., Shworak, N.W., Sina, P., Schwartz, J.J., Zhang, L., Fritze, L.M.S. and Rosenberg, R.D. (1999). „Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities”. J. Biol. Chem. 274: 5185—5192. PMID 9988768.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- (heparan+sulfate)-glucosamine+3-sulfotransferase+3 на US National Library of Medicine Medical Subject Headings (MeSH)
