Koenzim-B sulfoetiltiotransferaza

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Koenzim-B sulfoetiltiotransferaza
Identifikatori
EC broj 2.8.4.1
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

Koenzim-B sulfoetiltiotransferaza (EC 2.8.4.1, metil-KoM reduktaza, metil koenzim M reduktaza) je enzim sa sistematskim imenom metil-KoM:CoB S-(2-sulfoetil)tiotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

metil-KoM + CoB KoM-S-S-CoB + metan

Ovaj enzim katalizuje finalni korak metanogeneze.

Reference[уреди]

  1. Bobik, T.A., Olson, K.D., Noll, K.M. and Wolfe, R.S. (1987). „Evidence that the heterodisulfide of coenzyme-M and 7-mercaptanoylthreonine phosphate is a product of the methylreductase reaction in Methanobacterium”. Biochem. Biophys. Res. Commun. 149: 455—460. PMID 3122735. 
  2. Ellermann, J., Hedderich, R., Boecher, R. and Thauer, R.K. (1988). „The final step in methane formation: investigations with highly purified methyl coenzyme M reductase component C from Methanobacterium thermoautotrophicum (strain Marburg)”. Eur. J. Biochem. 184: 63—68. 
  3. Ermler, U., Grabarse, W., Shima, S., Goubeaud, M. and Thauer, R.K. (1997). „Crystal structure of methyl coenzyme M reductase: The key enzyme of biological methane formation”. Science. 278: 1457—1462. PMID 9367957. 
  4. Signor, L., Knuppe, C., Hug, R., Schweizer, B., Pfaltz, A. and Jaun, B. (2000). „Methane formation by reaction of a methyl thioether with a photo-excited nickel thiolate — a process mimicking methanogenesis in Archaea”. Chemistry. 6: 3508—3516. PMID 11072815. 
  5. Scheller, S., Goenrich, M., Boecher, R., Thauer, R.K. and Jaun, B. (2010). „The key nickel enzyme of methanogenesis catalyses the anaerobic oxidation of methane”. Nature. 465: 606—608. PMID 20520712. 

Literatura[уреди]

Spoljašnje veze[уреди]