Koenzim-B sulfoetiltiotransferaza

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Koenzim-B sulfoetiltiotransferaza
EC broj
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Koenzim-B sulfoetiltiotransferaza (EC, metil-KoM reduktaza, metil koenzim M reduktaza) je enzim sa sistematskim imenom metil-KoM:CoB S-(2-sulfoetil)tiotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

metil-KoM + CoB KoM-S-S-CoB + metan

Ovaj enzim katalizuje finalni korak metanogeneze.


  1. Bobik, T.A., Olson, K.D., Noll, K.M. and Wolfe, R.S. (1987). „Evidence that the heterodisulfide of coenzyme-M and 7-mercaptanoylthreonine phosphate is a product of the methylreductase reaction in Methanobacterium”. Biochem. Biophys. Res. Commun. 149: 455—460. PMID 3122735. 
  2. Ellermann, J., Hedderich, R., Boecher, R. and Thauer, R.K. (1988). „The final step in methane formation: investigations with highly purified methyl coenzyme M reductase component C from Methanobacterium thermoautotrophicum (strain Marburg)”. Eur. J. Biochem. 184: 63—68. 
  3. Ermler, U., Grabarse, W., Shima, S., Goubeaud, M. and Thauer, R.K. (1997). „Crystal structure of methyl coenzyme M reductase: The key enzyme of biological methane formation”. Science. 278: 1457—1462. PMID 9367957. 
  4. Signor, L., Knuppe, C., Hug, R., Schweizer, B., Pfaltz, A. and Jaun, B. (2000). „Methane formation by reaction of a methyl thioether with a photo-excited nickel thiolate — a process mimicking methanogenesis in Archaea”. Chemistry. 6: 3508—3516. PMID 11072815. 
  5. Scheller, S., Goenrich, M., Boecher, R., Thauer, R.K. and Jaun, B. (2010). „The key nickel enzyme of methanogenesis catalyses the anaerobic oxidation of methane”. Nature. 465: 606—608. PMID 20520712. 


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