Hondroitin 4-sulfotransferaza
(преусмерено са 3'-fosfoadenilil-sulfat:hondroitin 4'-sulfotransferaza)
| Hondroitin 4-sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.5 | ||||||||
| CAS broj | 83589-04-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hondroitin 4-sulfotransferaza (EC 2.8.2.5, hondroitinska sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:hondroitin 4'-sulfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + hondroitin adenozin 3',5'-bisfosfat + hondroitin 4'-sulfat
Sulfatacija se odvija u 4-poziciji N-acetil-galaktozaminskih ostataka hondroitina.
Reference[уреди | уреди извор]
- ^ Habuchi, O. & Miyashita, N. (1982). „Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage”. Biochim. Biophys. Acta. 717: 414—421. PMID 6957247.
- ^ Nakanishi, Y., Otsu, K. and Suzuki, S. (1983). „Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine”. FEBS Lett. 151: 15—18. PMID 6130977.
- ^ Nakanishi, Y., Shimizu, M., Otsu, K., Kato, S., Tsuji, M. and Suzuki, S. (1981). „A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate”. J. Biol. Chem. 256: 5443—5449. PMID 6787041.
- ^ Suzuki, S. & Strominger, J.L. (1960). „Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3′-phosphoadenosine 5′-phosphosulfate to mucopolysaccharides”. J. Biol. Chem. 235: 257—266. PMID 13835879.
- ^ Suzuki, S. & Strominger, J.L. (1960). „Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors”. J. Biol. Chem. 235: 267—273. PMID 13835880.
- ^ Suzuki, S. & Strominger, J.L. (1960). „Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondroitin and chondroitin sulfate A”. J. Biol. Chem. 235: 274—276. PMID 13835881.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Chondroitin+4-sulfotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
