5-Metiltetrahidrofolat:korinoid/gvožđe-sumpor protein Co-metiltransferaza
| 5-Metiltetrahidrofolat:korinoid/gvožđe-sumpor protein Co-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.258 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
5-Metiltetrahidrofolat:korinoid/gvožđe-sumpor protein Co-metiltransferaza (EC 2.1.1.258, acsE (gen)) je enzim sa sistematskim imenom 5-metiltetrahidrofolat:korinoid/gvožđe-sumporna proteinska metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- [metil-Co(III) korinoidni Fe-S protein] + tetrahidrofolat [Co(I) korinoidni Fe-S protein] + 5-metiltetrahidrofolat
Ovaj enzim katalizuje transfer metil grupe sa N5 pozicije metiltetrahidrofolata na 5-metoksibenzimidazolilkobamidni kofaktor korinoid/Fe-S proteina.
Reference
[уреди | уреди извор]- ^ Roberts, D.L., Zhao, S., Doukov, T. and Ragsdale, S.W. (1994). „The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum”. J. Bacteriol. 176: 6127—6130. PMID 7928975.
- ^ Doukov, T., Seravalli, J., Stezowski, J.J. and Ragsdale, S.W. (2000). „Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase”. Structure. 8: 817—830. PMID 10997901.
- ^ Doukov, T.I., Hemmi, H., Drennan, C.L. and Ragsdale, S.W. (2007). „Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases”. J. Biol. Chem. 282: 6609—6618. PMID 17172470.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 5-methyltetrahydrofolate:corrinoid/iron-sulfur+protein+Co-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
