DNK-3-metiladeninska glikozilaza II
| DNK-3-metiladeninska glikozilaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.21 | ||||||||
| CAS broj | 89287-38-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DNK-3-metiladeninska glikozilaza II (EC 3.2.2.21, dezoksiribonukleatna 3-metiladeninska glikozidaza II, 3-metiladeninska DNK glikozilaza II, DNK-3-metiladeninska glikozidaza II, AlkA) je enzim sa sistematskim imenom glikohidrolaza alkilisane DNK (otpuštanje metiladenina i metilguanina).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza alkilisane DNK uz oslobađanje 3-metiladenina, 3-metilguanina, 7-metilguanina i 7-metiladenina
Ovaj enzim učestvuje u uklanjanju alkilisanih baza sa DNK kod Escherichia coli.
Reference[уреди | уреди извор]
- ^ Evensen, G. & Seeberg, E. (1982). „Adaptation to alkylation resistance involves the induction of a DNA glycosylase”. Nature. 296: 773—775. PMID 7040984.
- ^ Karran, P., Hjelmgren, T. and Lindahl, T. (1982). „Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents”. Nature. 296: 770—773. PMID 7040983.
- ^ Riazuddin, S. & Lindahl, T. (1978). „Properties of 3-methyladenine-DNA glycosylase from Escherichia coli”. Biochemistry. 17: 2110—2118. PMID 352392.
- ^ Thomas, L., Yang, C.-H. and Goldthwait, D.A. (1982). „Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine”. Biochemistry. 21: 1162—1169. PMID 7041972.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- DNA-3-methyladenine+glycosylase+II на US National Library of Medicine Medical Subject Headings (MeSH)
