Delta8-masna-kiselina desaturaza
| Delta8-masna-kiselina desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.19.4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Delta8-masna-kiselina desaturaza (EC 1.14.19.4, Delta8-sfingolipidna desaturaza, EFD1, BoDES8, SLD, Delta8 masno kiselinska desaturaza, Delta8-desaturaza) je enzim sa sistematskim imenom fitosfinganin,vodonik donor:kiseonik Delta8-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fitosfinganin + redukovani akceptor + O2 Delta8-fitosfingenin + akceptor + 2H2O
Ovaj enzim je prisutan u mnogim biljkama. On uvodi dvostruku vezu u Delta8 kod C18 i C20 masnih kiselina.
Reference[уреди | уреди извор]
- ^ Wallis, J.G. & Browse, J. (1999). „The Δ8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids”. Arch. Biochem. Biophys. 365: 307—316. PMID 10328826.
- ^ Sperling, P., Libisch, B., Zähringer, U., Napier, J.A. and Heinz, E. (2001). „Functional identification of a Δ8-sphingolipid desaturase from Borago officinalis”. Arch. Biochem. Biophys. 388: 293—298. PMID 11368168.
- ^ Takakuwa, N., Kinoshita, M., Oda, Y. and Ohnishi, M. (2002). „Isolation and characterization of the genes encoding Δ8-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis'”. Curr. Microbiol. 45: 459—461. PMID 12402089.
- ^ Beckmann, C., Rattke, J., Oldham, N.J., Sperling, P., Heinz, E. and Boland, W. (2002). „Characterization of a Δ8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers”. Angew. Chem. Int. Ed. Engl. 41: 2298—2300. PMID 12203571.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Delta8-fatty-acid+desaturase на US National Library of Medicine Medical Subject Headings (MeSH)
