Dizopiramid

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Dizopiramid
Disopyramide.svg
Disopramide.png
IUPAC ime
(RS)-4-(diizopropilamino)-2-fenil-2-(piridin-2-il)butanamid
Klinički podaci
Prodajno imeNorpace
Drugs.comMonografija
MedlinePlusa682408
Kategorija trudnoće
  • AU: B2
  • US: C (Mogući rizik)
Način primeneOralno, intravenozno
Pravni status
Pravni status
Farmakokinetički podaci
BioraspoloživostVisoka
Vezivanje proteina50% do 65%
MetabolizamHepatički (CYP3A4-posredovano)
Poluvreme eliminacije6,7 sati (4 do 10 sati)
IzlučivanjeRenalno (80%)
Identifikatori
CAS broj3737-09-5 ДаY
ATC kodC01BA03 (WHO)
PubChemCID 3114
DrugBankDB00280 ДаY
ChemSpider3002 ДаY
UNIIGFO928U8MQ ДаY
KEGGD00303 ДаY
ChEBICHEBI:4657 ДаY
ChEMBLCHEMBL517 ДаY
Hemijski podaci
FormulaC21H29N3O
Molarna masa339,475 g/mol

Dizopiramid (INN, Norpace, Rythmodan) antiaritmički je lek, koji se koristi za tretiranje ventrikularne tahikardije.[1] On je blokator natrijumovog kanala i stoga se klasifikuje u klasu 1a anti-aritmičkih agenasa.[2][3] Dizopiramid ima negativno inotropno dejstvo na ventrikularni miokard. On znatno umanjuje kontraktilnost.[4][5] Dizopiramid takođe ima antiholinergički uticaj na srce, što uzrokuje mnoštvo nuspojava. Dizopiramid je dostupan u oralnoj i intravenoznoj formi, i ima nizak stepen toksičnosti.[6]

Hemija[уреди]

Dizopiramid se može sintetisati iz benzil cijanida i 2-bromopiridina:[7]

Disopyramide.png

Reference[уреди]

  1. ^ Guyton, Arthur C., Hall, John E. (2006). Textbook of Medical Physiology (11th ed.). Philadelphia: Elsevier Saunders
  2. ^ Rizos, I. I., et al. "Effects of Intravenous Disopyramide and Quinidine on Normal Myocardium and on the Characteristics of Arrhythmias: Intraindividual Comparison in Patients with Sustained Ventricular Tachycardia." European heart journal 8.2 (1987): 154-63. Biological Sciences. Web. 10 Feb. 2012
  3. ^ Kim, S. Y. SY, and N. L. NL Benowitz. "Poisoning due to Class IA Antiarrhythmic Drugs. Quinidine, Procainamide and Disopyramide." Drug safety : an international journal of medical toxicology and drug experience 5.6 (1990): 393-420. Biological Sciences; Environmental Science and Pollution Management. Web. 12 Feb. 2012.
  4. ^ Levites, R. R., and G. J. GJ Anderson. "Electrophysiological Effects of Disopyramide Phosphate during Experimental Myocardial Ischemia." American Heart Journal 98.3 (1979): 339-44. Biological Sciences. Web. 15 Feb. 2012.
  5. ^ Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012
  6. ^ Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012
  7. ^ U.S. Patent 3.225.054

Literatura[уреди]

  1. Guyton, Arthur C., Hall, John E. (2006). Textbook of Medical Physiology (11th ed.). Philadelphia: Elsevier Saunders.
  2. Rizos, I. I., et al. "Effects of Intravenous Disopyramide and Quinidine on Normal Myocardium and on the Characteristics of Arrhythmias: Intraindividual Comparison in Patients with Sustained Ventricular Tachycardia." European heart journal 8.2 (1987): 154-63. Biological Sciences. Web. 10 Feb. 2012.
  3. Katzung, Bertram G., Masters, Susan B., Trevor, Anthony J. (2009). Basic and Clinical Pharmacology (11th ed.). New York: McGraw Hill
  4. Levites, R. R., and G. J. GJ Anderson. "Electrophysiological Effects of Disopyramide Phosphate during Experimental Myocardial Ischemia." American Heart Journal 98.3 (1979): 339-44. Biological Sciences. Web. 15 Feb. 2012.
  5. Hulting J, Rosenhamer G: Hemodynamic and electrocardiographic effects of disopyramide in patients with ventricular arrhythmia. Acta Med Scand 199:41-51, 1976.
  6. Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012.
  7. Kim, S. Y. SY, and N. L. NL Benowitz. "Poisoning due to Class IA Antiarrhythmic Drugs. Quinidine, Procainamide and Disopyramide." Drug safety : an international journal of medical toxicology and drug experience 5.6 (1990): 393-420. Biological Sciences; Environmental Science and Pollution Management. Web. 12 Feb. 2012.

Spoljašnje veze[уреди]

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