Faktor VIII

Из Википедије, слободне енциклопедије
Koagulacioni faktor VIII, prokoagulantna komponenta
PDB prikaz paziran na 2R7E.
Dostupne strukture
1CFG, 1D7P, 1IQD, 2R7E, 3CDZ, 3HNB, 3HNY, 3HOB, 3J2Q, 3J2S, 4BDV
Identifikatori
Simboli F8; AHF; DXS1253E; F8B; F8C; FVIII; HEMA
Vanjski ID OMIM300841 MGI88383 HomoloGene49153 GeneCards: F8 Gene
Pregled RNK izražavanja
PBB GE F8 205756 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2157 14069
Ensembl ENSG00000185010 ENSMUSG00000031196
UniProt P00451 Q06194
RefSeq (mRNA) NM_000132 NM_001161373
RefSeq (protein) NP_000123 NP_001154845
Lokacija (UCSC) Chr HG1497_PATCH:
154.04 - 154.23 Mb
Chr X:
75.17 - 75.38 Mb
PubMed pretraga [1] [2]

Faktor VIII (FVIII) je esencijalni protein zgrušavanja krvi. On je takođe poznat kao antihemofilički faktor (AHF). Kod ljudi, faktor VIII je Kodiran F8 genom.[1][2] Defekti tog gena dovode do hemophilije A, recesivnog X-vezanog koagulacionog poremećaja.[3]

Reference[уреди]

  1. Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, Kaufman RJ, Brown E, Shoemaker C, Orr EC (1984). „Molecular cloning of a cDNA encoding human antihaemophilic factor”. Nature. 312 (5992): 342—7. PMID 6438528. doi:10.1038/312342a0. 
  2. Truett MA, Blacher R, Burke RL, Caput D, Chu C, Dina D, Hartog K, Kuo CH, Masiarz FR, Merryweather JP (1985). „Characterization of the polypeptide composition of human factor VIII:C and the nucleotide sequence and expression of the human kidney cDNA”. DNA. 4 (5): 333—49. PMID 3935400. doi:10.1089/dna.1985.4.333. 
  3. Antonarakis SE (1995). „Molecular genetics of coagulation factor VIII gene and hemophilia A”. Thromb. Haemost. 74 (1): 322—8. PMID 8578479. 

Literatura[уреди]

  • Gitschier J (1991). „The molecular basis of hemophilia A”. Ann. N. Y. Acad. Sci. 614 (1 Process in Va): 89—96. PMID 1902642. doi:10.1111/j.1749-6632.1991.tb43694.x. 
  • White GC, Shoemaker CB (1989). „Factor VIII gene and hemophilia A”. Blood. 73 (1): 1—12. PMID 2491949. 
  • Antonarakis SE, Kazazian HH, Tuddenham EG (1995). „Molecular etiology of factor VIII deficiency in hemophilia A”. Hum. Mutat. 5 (1): 1—22. PMID 7728145. doi:10.1002/humu.1380050102. 
  • Lenting PJ, van Mourik JA, Mertens K (1999). „The life cycle of coagulation factor VIII in view of its structure and function”. Blood. 92 (11): 3983—96. PMID 9834200. 
  • Saenko EL; Ananyeva N; Kouiavskaia D; et al. (2003). „Molecular defects in coagulation Factor VIII and their impact on Factor VIII function”. Vox Sang. 83 (2): 89—96. PMID 12201837. doi:10.1046/j.1423-0410.2002.00183.x. 
  • Lollar P (2003). „Molecular characterization of the immune response to factor VIII”. Vox Sang. 83. Suppl 1: 403—8. PMID 12617176. 
  • Fay PJ (2004). „Activation of factor VIII and mechanisms of cofactor action”. Blood Rev. 18 (1): 1—15. PMID 14684146. doi:10.1016/S0268-960X(03)00025-0. 
  • Lavigne-Lissalde G, Schved JF, Granier C, Villard S (2005). „Anti-factor VIII antibodies: a 2005 update”. Thromb. Haemost. 94 (4): 760—9. PMID 16270627. doi:10.1160/TH05-02-0118. 
  • Fang H, Wang L, Wang H (2007). „The protein structure and effect of factor VIII”. Thromb. Res. 119 (1): 1—13. PMID 16487577. doi:10.1016/j.thromres.2005.12.015. 

Spoljašnje veze[уреди]