Fizarolisin

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Fizarolisin
Identifikatori
EC broj3.4.21.103
CAS broj94949-28-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum

Fizarolisin (EC 3.4.21.103, Dictyostelium discoideum aspartička proteinaza, Dictyostelium discoideum aspartička proteinaza E, Physarum flavicomum aspartička proteinaza, Physarum policephalum kiselinska proteinaza, Physarum aspartička proteinaza, fizaropepsin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Zgrušavanje mleka. Preferentno razlaganje Gly8-Ser u B lancu insulina je najbrže, tome sledi Leu11-Val, Cys(SO3H)19-Gly i Phe24-Phe.

Ovaj enzim priapada peptidaznoj familiji S53.

Reference[уреди]

  1. ^ Henney, H.R. & Tavana, G. (1982). „Purification and some properties of an intracellular acid (carboxyl) proteinase from differentiating haploid cells of Physarum flavicomum”. Exp. Mycol. 6: 161—170. 
  2. ^ Murakami-Murofushi, K., Hiratsuka, A. and Ohta, J. (1984). „A novel acid protease from haploid amoebae of Physarum polycephalum, and its changes during mating and subsequent differentiation into diploid plasmodia”. Cell Struct. Funct. 9: 311—315. 
  3. ^ North, M.J. & Whyte, A. (1984). „Purification and characterization of two acid proteinases from Dictyostelium discoideum”. J. Gen. Microbiol. 130: 123—134. 
  4. ^ Wlodawer, A., Li, M., Gustchina, A., Oyama, H., Dunn, B.M. and Oda, K. (2003). „Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases”. Acta Biochim. Pol. 50: 81—102. PMID 12673349. 
  5. ^ Nishii, W., Ueki, T., Miyashita, R., Kojima, M., Kim, Y.T., Sasaki, N., Murakami-Murofushi, K. and Takahashi, K. (2003). „Structural and enzymatic characterization of physarolisin (formerly physaropepsin) proves that it is a unique serine-carboxyl proteinase”. Biochem. Biophys. Res. Commun. 301: 1023—1029. PMID 12589815. 

Literatura[уреди]

Spoljašnje veze[уреди]